ArticleAnnals of medicine2025
MiR-223-3p regulates erythropoiesis by targeting TGFBR3/Smad signaling pathway in hemoglobin H-Constant Spring disease.
Article in Annals of medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMicroRNAs (miRNAs) have emerged as regulators of pathogenesis in hematopoiesis by targeting post-transcription mRNA regulation. However, the involvement of miRNAs in hemoglobin H-Constant Spring (HbH-CS) disease remains unclear. The present study analyzed miRNAs differential expression profile between patients with HbH-CS disease and healthy subjects by Arraystar Human small RNA Microarray.
methodsThe differential expression profiles of miRNAs between HbH-CS patients and healthy individuals were analyzed using Arraystar human small RNA microarrays. Quantitative real-time PCR and Western blot were used to detect the mRNA and protein expression. Bioinformatics methods were used to predict the target genes of miRNAs, and the regulatory relationship between miRNAs and target genes was verified by dual-luciferase reporter assay. Cell apoptosis was detected by flow cytometry, and cell proliferative capacity was detected by CC K-8 assay.
resultsMiR-223-3p was significantly down-regulated in HbH-CS patients. Dual-luciferase reporter assay demonstrated that miR-223-3p specifically targeted TGFBR3. The
conclusionIn conclusion, this study indicated that the interaction between miR-223-3p and TGFBR3/Smad signaling pathway might affect erythropoiesis in HbH-CS disease, which can provide more information for the treatment of patients.
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