Evidence map›Paper›PMID 40646607›Full record

ArticleClinical epigenetics2025

Insulin levels at 18-20 gestational weeks in pregnant women with obesity are associated with newborn abdominal fat deposition and DNA methylation in cord blood.

Alice Maguolo, Josefine Jönsson, Alexander Perfilyev, Allan Vaag, Emma Malchau Carlsen, Kirsten Nørgaard, Paul W Franks, Kristina M Renault, Charlotte Ling

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical epigenetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Alice MaguoloEpigenetics and Diabetes Unit, Department of Clinical Sciences in Malmö, Lund University Diabetes Centre, Scania University Hospital, Malmö, Sweden. alice.maguolo@med.lu.se.
Josefine JönssonEpigenetics and Diabetes Unit, Department of Clinical Sciences in Malmö, Lund University Diabetes Centre, Scania University Hospital, Malmö, Sweden.
Alexander PerfilyevEpigenetics and Diabetes Unit, Department of Clinical Sciences in Malmö, Lund University Diabetes Centre, Scania University Hospital, Malmö, Sweden.
Allan VaagDepartment of Clinical Sciences in Malmö, Lund University Diabetes Centre, Scania University Hospital, Malmö, Sweden.
Emma Malchau CarlsenDepartment of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Frederiksberg, Denmark.
Kirsten NørgaardCopenhagen University Hospital-Steno Diabetes Center Copenhagen, Borgmester Ib Juuls Vej 83, 2730, Herlev, Denmark.
Paul W FranksDepartment of Clinical Sciences in Malmö, Lund University Diabetes Centre, Scania University Hospital, Malmö, Sweden.
Kristina M RenaultDepartment of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, 2200, Copenhagen N, Denmark.
Charlotte LingEpigenetics and Diabetes Unit, Department of Clinical Sciences in Malmö, Lund University Diabetes Centre, Scania University Hospital, Malmö, Sweden. charlotte.ling@med.lu.se.

Funding

European Research Council CoG-2015_681742_NASCENTObelisk European Union's Horizon Europe Research and Innovation programme 101080465Strategic Research Area Exodiab 2009-1039Sygekassernes Helsefond 2008B081
6 · The paper itself

Abstract

We assessed if fasting plasma insulin levels in pregnant women with obesity are associated with newborns' abdominal fat deposition (dual-energy X-ray absorptiometry) and with cord blood DNA methylation (450k array) in 232 mother-child pairs from the Treatment of Obese Pregnant women (TOP) study. Fasting maternal insulin at 18-20gw was associated with abdominal/total fat mass ratio in newborns independent of multiple potential confounders (β = 0.23[95%CI: 0.01; 0.45], P = 0.041) and with cord blood DNA methylation at CpG sites annotated to C11orf54 and RARB (FDR < 10%), both genes potentially involved in metabolic programming. In conclusion, maternal insulin levels in pregnancy were associated with adiposity traits and epigenetics in the offspring.

Indexed as

Abdominal FatDNA MethylationFetal BloodInsulinObesityPregnancy ComplicationsAbsorptiometry, PhotonAdultCpG IslandsEpigenesis, GeneticFemaleGestational AgeHumansInfant, NewbornPregnancyInsulinAbdominal adiposityBody compositionDiabetesDNA methylationEarly lifeEpigeneticsFetal programmingMaternal insulin

Identifiers

PMID40646607
PMCPMC12255083

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.