Evidence map›Paper›PMID 40646571›Full record

ArticleDiabetology & metabolic syndrome2025

Neutral Protamine Hagedorn (NPH) insulin attenuates memory impairments in diabetic rats.

Marcelo T Andrade, Camila B Gomes, Débora O Fernandes, Bruno P Melo, Michele M Moraes, Ana F S Almeida, Laura F J Alvarado, Grace S Pereira, Juliana B Guimarães, Elsa Heyman and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Diabetology & metabolic syndrome, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Marcelo T AndradeExercise Physiology Laboratory, School of Physical Education, Physiotherapy and Occupational Therapy, Universidade Federal de Minas Gerais, Av. Antônio Carlos, Belo Horizonte, MG, 662731270-901, Brazil.
Camila B GomesExercise Physiology Laboratory, School of Physical Education, Physiotherapy and Occupational Therapy, Universidade Federal de Minas Gerais, Av. Antônio Carlos, Belo Horizonte, MG, 662731270-901, Brazil.
Débora O FernandesExercise Physiology Laboratory, School of Physical Education, Physiotherapy and Occupational Therapy, Universidade Federal de Minas Gerais, Av. Antônio Carlos, Belo Horizonte, MG, 662731270-901, Brazil.
Bruno P MeloExercise Physiology Laboratory, School of Physical Education, Physiotherapy and Occupational Therapy, Universidade Federal de Minas Gerais, Av. Antônio Carlos, Belo Horizonte, MG, 662731270-901, Brazil.
Michele M MoraesExercise Physiology Laboratory, School of Physical Education, Physiotherapy and Occupational Therapy, Universidade Federal de Minas Gerais, Av. Antônio Carlos, Belo Horizonte, MG, 662731270-901, Brazil.
Ana F S AlmeidaDepartment of Physiology and Biophysics, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
Laura F J AlvaradoDepartment of Physiology and Biophysics, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
Grace S PereiraDepartment of Physiology and Biophysics, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
Juliana B GuimarãesState University of Minas Gerais - Ibirité Unit, Ibirité, Brazil.
Elsa HeymanULR 7369-URePSSS-Unité de Recherche Pluridisciplinaire Sport Santé Société, Institut Universitaire de France (IUF), Univ. Lille, Univ. Artois, Univ. Littoral Côte d'Opale, Lille, France.
Romain MeeusenHuman Physiology & Sports Physiotherapy Research Group, Faculty of Physical Education and Physical Therapy, Vrije Universiteit Brussel, Brussels, Belgium.
Thiago T MendesExercise Physiology and Health Laboratory, Universidade Federal da Bahia, Salvador, Brazil.
Danusa D SoaresExercise Physiology Laboratory, School of Physical Education, Physiotherapy and Occupational Therapy, Universidade Federal de Minas Gerais, Av. Antônio Carlos, Belo Horizonte, MG, 662731270-901, Brazil. danusa56@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cognitive decline is a significant complication of type 1 diabetes (T1D) that substantially affects patients' quality of life. Although previous studies suggest that Neutral Protamine Hagedorn (NPH) insulin may mitigate certain effects of streptozotocin-induced type 1 diabetes (T1D

Indexed as

Cognitive impairmentDiabetes complicationsInsulin therapyMemory deficitsNeuroprotectionStreptozotocin-induced diabetes

Identifiers

PMID40646571
PMCPMC12255018

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.