Evidence map›Paper›PMID 40646565›Full record

ArticleBiotechnology for biofuels and bioproducts2025

Energetic constraints of metal-reducing bacteria as biocatalysts for microbial electrosynthesis.

Shaylynn D Miller, Kathryne C Ford, Megan C Gruenberg Cross, Michaela A TerAvest

Abstract read
In one paragraph

Article in Biotechnology for biofuels and bioproducts, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Shaylynn D MillerDepartment of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI, USA.ORCID http://orcid.org/0009-0007-6351-0517
Kathryne C FordDepartment of Microbiology and Molecular Genetics, Michigan State University, East Lansing, MI, USA.ORCID http://orcid.org/0000-0002-6357-9318
Megan C Gruenberg CrossDepartment of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI, USA.ORCID http://orcid.org/0000-0002-9158-9900
Michaela A TerAvestDepartment of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI, USA. teraves2@msu.edu.ORCID http://orcid.org/0000-0002-5435-3587

Funding

National Science Foundation 1750785
6 · The paper itself

Abstract

backgroundAs outlined by the Intergovernmental Panel on Climate Change, we need to approach global net zero CO

resultsWe modeled the Gibbs free energy change for electron transfer from respiratory quinones to NADH under conditions reflecting changes in membrane potential, pH, reactant to product ratio, and energetically coupled IMF. Of the 40 conditions modeled for each method of energetic coupling (PMF, SMF, and uncoupled), none were thermodynamically favorable without PMF or SMF. We also found that membrane potential decreased upon initiation of EEU to NAD

conclusionsOur results suggest that Q-pool-dependent EEU is both IMF-dependent and is IMF-limited in a proof-of-concept system. Because microbes that rely on Q-pool-dependent EEU are among the most genetically tractable and metabolically flexible options for MES systems, it is important that we account for this thermodynamic bottleneck in future MES platform designs.

Identifiers

PMID40646565
PMCPMC12247439

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.