ArticleAIDS research and therapy2025
Risk of uveitis in patients with human immunodeficiency virus: a cohort study through TriNetX database.
Article in AIDS research and therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Post-operative bilateral anterior uveitis: a rare case of ocular complication associated with anti-adhesion agent use in obstetric and gynaecologic surgery.Journal of surgical case reports · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis multi-institutional, retrospective cohort study using TriNetX database aims to explore the relationship between HIV infection and uveitis.
methodsHIV patients were propensity-matched to individuals from our non-HIV cohort (1:1 ratio) based on variables such as age (every 5 year), sex, ethnicity, race, and relevant comorbidities. The Cox proportional hazards regression model was utilized to assess the impact of variables on uveitis risk, reporting hazard ratios (HRs) with 95% confidence intervals (CIs). Kaplan-Meier survival analysis and log-rank tests were applied to estimate the cumulative incidence of uveitis. Statistical significance was set at a two-sided p-value < 0.05.
resultsWe found that adult patients with HIV infection had a significantly increased risk of developing uveitis compared to non-HIV counterparts, with an overall HR of 3.02 (95% CI: 2.70 - 3.39). The risk remained elevated across designated follow-up intervals of 1 year (HR = 4.68 [3.69 - 5.92]), 2 years (HR = 4.44 [3.65 - 5.41]), and 3 years (HR = 4.06 [3.42 - 4.81]), with consistent increases noted when dividing into different uveitis types except for anterior uveitis. The risk was higher among patients with acquired immunodeficiency syndrome (AIDS) compared to asymptomatic HIV (HR = 2.64 [1.30 - 5.35]). Furthermore, HIV patients receiving treatment within three months exhibited a notably increased risk (HR = 2.87 [2.33 - 3.54]).
conclusionsThis study reveals that individuals with HIV face a significantly heightened risk of developing uveitis. Our findings indicate that this risk is most substantial for intermediate and posterior uveitis, challenging the long-held belief that anterior uveitis is the predominant form in this population.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.