Evidence map›Paper›PMID 40646529›Full record

ArticleJournal of nanobiotechnology2025

USP5 inhibition via bone marrow-targeted engineered exosomes for myeloproliferative neoplasms therapy.

Wenjun Wang, Yufeng Jiang, Donglei Zhang, Xian Zhang, Qian Liang, Jun Shi, Yuan Zhou, Fuling Zhou

Abstract read
In one paragraph

Article in Journal of nanobiotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Wenjun WangDepartment of Hematology, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan, 430071, China.
Yufeng JiangSchool of Information and Mathematics, Yangtze University, Jingzhou, Hubei, 434000, China.
Donglei ZhangDepartment of Hematology, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan, 430071, China.
Xian ZhangDepartment of Hematology, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan, 430071, China.
Qian LiangState Key Laboratory of Experimental Hematology, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, National Clinical Research Center for Blood Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, 300020, China.
Jun ShiState Key Laboratory of Experimental Hematology, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, National Clinical Research Center for Blood Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, 300020, China. shijun@ihcams.ac.cn.
Yuan ZhouState Key Laboratory of Experimental Hematology, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, National Clinical Research Center for Blood Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, 300020, China. yuanzhou@ihcams.ac.cn.
Fuling ZhouDepartment of Hematology, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan, 430071, China. zhoufuling@whu.edu.cn.

Funding

grants National Natural Science Foundation of China 81770179grants National Natural Science Foundation of China 82270148
6 · The paper itself

Abstract

Myeloproliferative neoplasms (MPNs) are challenging to treat due to the complex bone marrow (BM) microenvironment and lack of curative therapies. Current treatments fail to eliminate malignant clones and face issues like drug resistance. This study addressed these challenges by identifying USP5 as a critical regulator in JAK2

Indexed as

Bone MarrowExosomesMyeloproliferative DisordersUbiquitin-Specific ProteasesAnimalsApoptosisCell ProliferationHumansMesenchymal Stem CellsMiceReceptors, CXCR4Receptors, CXCR4Ubiquitin-Specific ProteasesBone marrow targetingDeubiquitinating enzymeMesenchymal stem cellsMyeloproliferative neoplasms

Identifiers

PMID40646529
PMCPMC12247442

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.