Evidence map›Paper›PMID 40646472›Full record

Trial reportBMC pregnancy and childbirth2025

Effect of vitamin D

Anita Subramanian, Casey M Carr, Eszter Papp, Kellie E Murphy, Abdullah Al Mahmud, Daniel E Roth, Alison D Gernand

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC pregnancy and childbirth, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Anita SubramanianDepartment of Nutritional Sciences, The Pennsylvania State University, 110 Chandlee Laboratory, University Park, PA, 16802, USA.
Casey M CarrDepartment of Biology, Eberly College of Science, The Pennsylvania State University, University Park, PA, USA.
Eszter PappCentre for Global Child Health, Hospital for Sick Children, Toronto, Canada.
Kellie E MurphyDepartment of Obstetrics and Gynecology, Mt. Sinai Hospital, Toronto, Canada.
Abdullah Al MahmudNutrition and Clinical Services Division, icddr, b, Dhaka, Bangladesh.
Daniel E RothCentre for Global Child Health, Hospital for Sick Children, Toronto, Canada.
Alison D GernandDepartment of Nutritional Sciences, The Pennsylvania State University, 110 Chandlee Laboratory, University Park, PA, 16802, USA. adg14@psu.edu.

Funding

Bill & Melinda Gates Foundation OPP1066764
6 · The paper itself

Abstract

backgroundAngiogenesis is essential for placental growth and development. Improper placental vascular development can reduce blood flow to the fetus and increase the risk of adverse pregnancy and birth outcomes. The objectives of this study were to examine the effect of prenatal vitamin D supplementation on placental angiogenic factors and terminal villi, and associations between angiogenic factors, terminal villi and birth outcomes.

methodsThis is a secondary analysis using data and specimens from the Maternal Vitamin D for Infant Growth trial in Dhaka, Bangladesh (n = 1298). Participants were enrolled at 17-24 weeks gestation and randomized to receive (IU/week): placebo, 4200, 16,800 or 28,000 vitamin D

resultsThe overall mean (SD) percent area of expression was 17.0 (4.0) for VEGF-A and 15.0 (1.9) for PlGF. The mean (SD) number of terminal villi was 39 (15) per 12 in

conclusionsVitamin D supplementation starting from mid-pregnancy until birth did not affect expression of two key angiogenic factors or terminal villi in the placenta. Placental angiogenic factors or terminal villi did not have an association with birth outcomes. These results do not support a role of maternal vitamin D starting mid-pregnancy in impacting placental development.

Indexed as

CholecalciferolChorionic VilliDietary SupplementsPlacentaPlacenta Growth FactorVitaminsAdultBangladeshFemaleHumansInfant, NewbornMaleNeovascularization, PhysiologicPlacentationPregnancyPregnancy OutcomeCholecalciferolPGF protein, humanPlacenta Growth FactorVascular Endothelial Growth Factor AVEGFA protein, humanVitaminsAngiogenic factorsPlacentaPlacental angiogenesisPregnancyTrophoblastVasculatureVilliVitamin D

Identifiers

PMID40646472
PMCPMC12255087

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.