ArticleBMC neurology2025
Transcriptome profiling reveals major structural genes, transcription factors and biosynthetic pathways in refractory epilepsy in tropical region of China.
Article in BMC neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Extracellular vesicle signatures from eye lavage as novel non-invasive biomarkers for hypoxic ischaemic insult-findings from a neonatal mouse model.Frontiers in medical technology · 2025Article
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9 authors.
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Abstract
backgroundEpilepsy is a chronic neurological disorder known for its recurring seizures, prolonged course, and unpredictability. Importantly, a group of patients with refractory epilepsy do not respond to pharmacological treatments, even though they show symptoms similar to those of drug-responsive epilepsy. This situation creates substantial challenges in diagnosing and managing the disorder. In tropical regions, specific environmental and economic factors intensify the socio-economic impact. Consequently, discovering blood-based biomarkers for tropical refractory epilepsy is highly valuable for developing prevention and treatment approaches.
methodsIn our study, we used RNA sequencing (RNA-seq) to examine the peripheral blood transcriptomes of both healthy individuals and patients with tropical refractory epilepsy.
resultsOur analysis identified a total of 3,381 differentially expressed genes (DEGs). Using bioinformatics tools and manual verification, we pinpointed CAMK2A, CAMK2B, and CAMK2D as key genes potentially involved in tropical refractory epilepsy. Moreover, our comparison of alternative splicing (AS) patterns between healthy individuals and patients revealed 1,471 differentially alternative splicing (DAS) events.
conclusionsThe interactions between CAMK2A, CAMK2B, CAMK2D, and PDE4B, CYBB, RAP1A, RAP1B, CALM1, FLNA, ATF4, PLCB2 could underlie potential mechanisms of tropical RE.
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