Trial reportNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2025
The impact of transcranial direct current stimulation on brain network connectivity and topology in post-stroke cognitive impairment patients: a resting-state fMRI study.
Trial report in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Interventions for post-stroke cognitive impairment: a systematic review of neuroplastic mechanisms, comparative efficacy, and multimodal approaches.Frontiers in neuroscience · 2026Pooled it
- Dual Transcranial Direct Current Stimulation Modulates Hierarchical Functional Network Organization in Post-Stroke Cognitive Impairment: A Randomized Controlled Trial.CNS neuroscience & therapeutics · 2026Trial
- Topological Alterations of Functional Brain Networks in Post-Stroke Cognitive Impairment: a Graph-Theoretical Study.Clinical neuroradiology · 2026Article
- Acupuncture for Post-Stroke Cognitive Impairment: Mechanisms and Clinical Evidence (2020-2025).Neuropsychiatric disease and treatment · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPost-stroke cognitive impairment (PSCI) is a common and severe consequence of ischemic stroke (IS) that significantly affects patient outcomes. Transcranial direct current stimulation (tDCS) has shown promise in enhancing cognitive function in IS patients, but its underlying mechanisms are not fully understood. This study investigates the effects of tDCS on brain functional connectivity and network topology using resting-state functional magnetic resonance imaging (rs-fMRI).
methodsIn this double-blind study, sixty-five IS patients with PSCI were randomly assigned to either the tDCS or control group. Rs-fMRI data were acquired before and after the intervention. We analyzed functional connectivity (FC) and graph theory-based topological properties. Cognitive performance was assessed using the Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA). RESULTS AFTER: treatment, both groups showed improvements in MMSE and MoCA scores, with the tDCS group demonstrating significantly greater improvements (p < 0.05). In the tDCS group, FC significantly increased between four pairs of brain regions (p < 0.05, FDR-corrected). Additionally, Global Efficiency (E
conclusionThese findings suggest that tDCS improves cognitive function in PSCI by altering brain network connectivity and topological organization, providing neuroimaging evidence to support its therapeutic mechanisms.
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