Evidence map›Paper›PMID 40646375›Full record

ArticleMolecular and cellular biochemistry2025

Mechanism of hydrogen-rich water alleviating radiation-induced cognitive impairment through PI3K/AKT/Caspase-9 pathway mediating anti-oxidation.

Mengya Liu, Yong Wang, Yuhao Wang, Huan Liu, Jianhua Li, Jianguo Li, Xiujun Qin

Abstract read
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In one paragraph

Article in Molecular and cellular biochemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Mengya Liu *Shanxi Key Laboratory for Pharmaceutical Toxicology & Radiation Injury Pharmaceuticals/CNNC Key Laboratory for Radiotoxicology and Preclinical Assessment of Radio-Pharmaceuticals, Department of Radiology and Environmental Medicine, China Institute for Radiation Protection, #102 Xuefu Road, Taiyuan, 030006, Shanxi, China.
Yong Wang *Shanxi Key Laboratory for Pharmaceutical Toxicology & Radiation Injury Pharmaceuticals/CNNC Key Laboratory for Radiotoxicology and Preclinical Assessment of Radio-Pharmaceuticals, Department of Radiology and Environmental Medicine, China Institute for Radiation Protection, #102 Xuefu Road, Taiyuan, 030006, Shanxi, China.
Yuhao WangShanxi Key Laboratory for Pharmaceutical Toxicology & Radiation Injury Pharmaceuticals/CNNC Key Laboratory for Radiotoxicology and Preclinical Assessment of Radio-Pharmaceuticals, Department of Radiology and Environmental Medicine, China Institute for Radiation Protection, #102 Xuefu Road, Taiyuan, 030006, Shanxi, China.
Huan LiuShanxi Key Laboratory for Pharmaceutical Toxicology & Radiation Injury Pharmaceuticals/CNNC Key Laboratory for Radiotoxicology and Preclinical Assessment of Radio-Pharmaceuticals, Department of Radiology and Environmental Medicine, China Institute for Radiation Protection, #102 Xuefu Road, Taiyuan, 030006, Shanxi, China.
Jianhua LiShanxi Key Laboratory for Pharmaceutical Toxicology & Radiation Injury Pharmaceuticals/CNNC Key Laboratory for Radiotoxicology and Preclinical Assessment of Radio-Pharmaceuticals, Department of Radiology and Environmental Medicine, China Institute for Radiation Protection, #102 Xuefu Road, Taiyuan, 030006, Shanxi, China.
Jianguo LiShanxi Key Laboratory for Pharmaceutical Toxicology & Radiation Injury Pharmaceuticals/CNNC Key Laboratory for Radiotoxicology and Preclinical Assessment of Radio-Pharmaceuticals, Department of Radiology and Environmental Medicine, China Institute for Radiation Protection, #102 Xuefu Road, Taiyuan, 030006, Shanxi, China.
Xiujun QinShanxi Key Laboratory for Pharmaceutical Toxicology & Radiation Injury Pharmaceuticals/CNNC Key Laboratory for Radiotoxicology and Preclinical Assessment of Radio-Pharmaceuticals, Department of Radiology and Environmental Medicine, China Institute for Radiation Protection, #102 Xuefu Road, Taiyuan, 030006, Shanxi, China. xiujunqin@163.com.

Funding

Natural Science Foundation of Shanxi Province 202203021211005
6 · The paper itself

Abstract

Explore the mechanism by which the antioxidant effect of hydrogen-rich water alleviates radiation-induced cognitive impairment based on the PI3K/AKT/Caspase-9 signaling pathway. Male SD rats were randomly divided into control group (Control group), simple irradiation (IR) group, high-dose hydrogen-rich water intervention (IR + HHRW) group, and low-dose hydrogen-rich water intervention (IR + LHRW) group. The irradiation dose was 20 Gy, and the whole brain was irradiated. The control group and IR group were given pure water (20 mL·kg

Indexed as

AntioxidantsCaspase 9Cognitive DysfunctionHydrogenPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktRadiation Injuries, ExperimentalSignal TransductionWaterAnimalsMaleRatsRats, Sprague-DawleyAntioxidantsCasp9 protein, ratCaspase 9HydrogenPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktWaterHydrogen-rich waterIonizing radiationNerve cell apoptosisPI3K/AKT/Caspase-9 signaling pathwayRadiation-induced cognitive impairment

Identifiers

PMID40646375

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.