Evidence map›Paper›PMID 40646365›Full record

ReviewCurrent pain and headache reports2025

Clinical Efficacy and Risks of Intradiscal Orthobiological Injections: A Narrative Review.

Macie A Serio, Rachael Bartolina, Sanjana Sudini, Ellie M MacDonald, Austin S Thomassen, Sahar Shekoohi, Azem A Chami, Alan D Kaye

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current pain and headache reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Macie A SerioSchool of Medicine, Louisiana State University Health Sciences Center at Shreveport, Shreveport, LA, 71103, USA.
Rachael BartolinaSchool of Medicine, Louisiana State University Health Sciences Center at Shreveport, Shreveport, LA, 71103, USA.
Sanjana SudiniUniversity of Alabama at Birmingham, 1720 University Blvd, Birmingham, AL, 35294, USA.
Ellie M MacDonaldSchool of Medicine, Louisiana State University Health Sciences Center at Shreveport, Shreveport, LA, 71103, USA.
Austin S ThomassenSchool of Medicine, Louisiana State University Health Sciences Center at Shreveport, Shreveport, LA, 71103, USA.
Sahar ShekoohiDepartment of Anesthesiology, Louisiana State University Health Sciences Center Shreveport, Shreveport, LA, 71103, USA. sahar.shekoohi@lsuhs.edu.
Azem A ChamiDepartment of Anesthesiology, Louisiana State University Health Sciences Center Shreveport, Shreveport, LA, 71103, USA.
Alan D KayeDepartments of Anesthesiology and Pharmacology, Toxicology, and Neurosciences, Louisiana State University Health Sciences Center Shreveport, Shreveport, LA, 71103, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purpose of reviewChronic discogenic low back pain (LBP) is a common cause of disability worldwide. Current management options include conservative, surgical, and minimally invasive interventional injections. Intradiscal orthobiological injections of platelet-rich plasma (PRP), bone marrow aspirate concentrate (BMAC), and mesenchymal stem cells (MSCs) have been introduced as regenerative treatment options. RECENT

findingsMany studies have demonstrated improvements in patients' reported outcomes (PROMs) measuring the areas of pain, disability, function, and satisfaction. The results are promising with statistical improvements shown throughout various studies. Adverse events such as increased pain and infection have been reported with these injections; however, the complication rate has yet to be delineated. Numerous studies report no adverse events in their sample size. The present investigation summarizes recent evidence for the efficacy and risks of PRP, BMAC, and MSC injections.

Indexed as

Bone Marrow TransplantationLow Back PainMesenchymal Stem Cell TransplantationPlatelet-Rich PlasmaHumansInjections, SpinalTreatment OutcomeBone marrow aspirate concentrate (BMAC)Chronic LBPDegenerative disc disease (DDD)Discogenic LBPIntradiscal orthobiological injectionsLow back pain (LBP)Mesenchymal stem cells (MSCs)Patient-reported outcome measures (PROMs)Platelet-rich plasma (PRP)

Identifiers

PMID40646365

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.