Evidence map›Paper›PMID 40646345›Full record

ReviewCurrent oncology reports2025

Brain Tumor Related Epilepsy: Pathophysiology and Multimodal Approach to Management.

Tyler Heinrich, Vishal Pandya

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current oncology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Tyler HeinrichComprehensive Epilepsy Center, Department of Neurology, Medical College of Wisconsin, 9200 W. Wisconsin Ave., Milwaukee, WI, 53226, USA.
Vishal PandyaComprehensive Epilepsy Center, Department of Neurology, Medical College of Wisconsin, 9200 W. Wisconsin Ave., Milwaukee, WI, 53226, USA. vpandya@mcw.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purpose of reviewPatients with brain tumor related epilepsy (BTRE) represent a heterogenous group whose management is complicated by two distinct but interrelated disease processes. Current medical literature remains limited in its ability to guide an individualized approach to treatment. This review aims to present a holistic evaluation of the literature in BTRE with attention to recent scientific developments. RECENT

findingsThe bidirectional pathophysiology of epileptogenesis and tumorigenesis is being targeted for potential treatment options, including repurposing anti-seizure medications. Broad recommendations can be abstracted from the current literature regarding appropriate pharmacological prophylaxis, the effectiveness of surgical resection, and potential utility of neuromodulation. BTRE is most effectively managed when addressing the particular oncologic disease as well as epilepsy as interdependent processes. Treatment should aim to balance seizure control with adverse effects and quality of life. Future studies with a focus on this framework will advance an individualized approach.

Indexed as

Brain NeoplasmsEpilepsyAnticonvulsantsCombined Modality TherapyHumansQuality of LifeAnticonvulsantsBrain tumorBrain tumor related epilepsyBTREEpilepsyEpileptogenesisSeizureTumorigenesis

Identifiers

PMID40646345

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.