ArticleSurgical endoscopy2025
Pragmatic approach to implementation of universal MSI testing for new cases of colorectal cancer.
Article in Surgical endoscopy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
- Erratum issued
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMicrosatellite instability testing is used in cases of colorectal cancer to help identify individuals with Lynch syndrome. There is clinical, but not financial case for this testing. Net Present Value (NPV) is a financial tool designed to calculate whenever investment in the new project is financially sound. We hypothesize that investment into uniform testing on all new colorectal cancers will generate profit over time.
methodsFinancial model was created based on number of patients seen and tested at tertiary medical center.
resultsUniform testing will cost $209 per patients (four test at $52.25 per test) and $5,000 is expected to be spent on pathology technician time. In that cohort, 8 out of 200 patients (equal number of males and females) is expected to be identified as having Lynch syndrome. Based on current charges, 5-year NPV is positive at $110,000 and 10-year NPV is positive at $199.663.
conclusionsInitial investment into MSI testing on all new cases of colorectal cancer results positive NPV and can help make a case for uniform testing to the hospital.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.