Evidence map›Paper›PMID 40646309›Full record

ArticleNature structural & molecular biology2025

A heterotrimeric protein complex assembles the metazoan V-ATPase upon dissipation of proton gradients.

Christopher Nardone, Julian Mintseris, Dingwei He, Justine C Rutter, Benjamin L Ebert, Steven P Gygi, Tom Rapoport

Abstract read
In one paragraph

Article in Nature structural & molecular biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Compartmental pH regulation in cancer and antitumor immunity: therapeutic opportunities and challenges.Apoptosis : an international journal on programmed cell death · 2026
    Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Christopher NardoneDepartment of Cell Biology, Harvard Medical School, Boston, MA, USA. christopher_nardone@hms.harvard.edu.ORCID http://orcid.org/0000-0002-1705-5310
Julian MintserisDepartment of Cell Biology, Harvard Medical School, Boston, MA, USA.
Dingwei HeDepartment of Cell Biology, Harvard Medical School, Boston, MA, USA.
Justine C RutterDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
Benjamin L EbertDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.ORCID http://orcid.org/0000-0003-0197-5451
Steven P GygiDepartment of Cell Biology, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0001-7626-0034
Tom RapoportDepartment of Cell Biology, Harvard Medical School, Boston, MA, USA. tom_rapoport@hms.harvard.edu.ORCID http://orcid.org/0000-0001-9911-4216

Funding

Medical Scientist Training ProgramT32GM144273 · NIGMS · HARVARD MEDICAL SCHOOL · PI David Shumway Jones, Jacqueline A. Lees · 2022 to 2026
$14.7M
NIGMS NIH HHS T32 GM144273
6 · The paper itself

Abstract

Organelles such as lysosomes and synaptic vesicles are acidified by V-ATPases, which consist of a cytosolically oriented V

Indexed as

Vacuolar Proton-Translocating ATPasesAnimalsHumansLysosomesModels, MolecularProtonsProtonsVacuolar Proton-Translocating ATPases

Identifiers

PMID40646309
PMCPMC12527914

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.