Evidence map›Paper›PMID 40646293›Full record

ArticleCommunications medicine2025

Continuous vital sign monitoring of acute Lassa fever using wearable biosensor devices in West Africa.

Brady Page, Raphaëlle Klitting, Matthias G Pauthner, Steven Steinhubl, Stephan Wegerich, Margaret Kaiser, Foday Alhasan, Edwin Konuwa, Veronica Koroma, Ibrahim Sumah and 13 more

Abstract read
In one paragraph

Article in Communications medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Brady PageUniversity of California, San Diego (UCSD), La Jolla, CA, USA. bpage@ucsd.edu.ORCID http://orcid.org/0009-0000-4306-4440
Raphaëlle KlittingScripps Research Institute, La Jolla, CA, USA.
Matthias G PauthnerScripps Research Institute, La Jolla, CA, USA.ORCID http://orcid.org/0000-0001-9212-4307
Steven SteinhublScripps Research Institute, La Jolla, CA, USA.ORCID http://orcid.org/0000-0002-9256-7914
Stephan WegerichProlaio, Inc, Scottsdale, AZ, USA.
Margaret KaiserIndependent researcher, Greenville, SC, USA.
Foday AlhasanKenema Government Hospital, Kenema, Sierra Leone.
Edwin KonuwaKenema Government Hospital, Kenema, Sierra Leone.
Veronica KoromaKenema Government Hospital, Kenema, Sierra Leone.
Ibrahim SumahKenema Government Hospital, Kenema, Sierra Leone.
Jenneh BrimaKenema Government Hospital, Kenema, Sierra Leone.
Tiangay KallonKenema Government Hospital, Kenema, Sierra Leone.
Brima JusuKenema Government Hospital, Kenema, Sierra Leone.
Sia Mator-MabayKenema Government Hospital, Kenema, Sierra Leone.
Mohamed KamaraKenema Government Hospital, Kenema, Sierra Leone.
Fatima KamaraKenema Government Hospital, Kenema, Sierra Leone.
Emilia JawardKenema Government Hospital, Kenema, Sierra Leone.
Angella MassallyKenema Government Hospital, Kenema, Sierra Leone.
Zainab KannehKenema Government Hospital, Kenema, Sierra Leone.
Michelle McGrawScripps Research Institute, La Jolla, CA, USA.
John SchieffelinTulane University School of Medicine, New Orleans, LA, USA.
Donald GrantKenema Government Hospital, Kenema, Sierra Leone.
Kristian G AndersenScripps Research Institute, La Jolla, CA, USA.ORCID http://orcid.org/0000-0001-6431-5982

Funding

Technology CoreU19AI135995 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI Bryan Briney · 2018 to 2026
$32.0M
NIAID NIH HHS U19 AI135995U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) U19AI135995
6 · The paper itself

Abstract

backgroundLassa fever is a fulminant viral illness associated with high in-hospital mortality. This disease constitutes a serious public health concern in West Africa, in particular Nigeria and the Mano River Union region (Guinea, Liberia, and Sierra Leone). In Sierra Leone, continuous monitoring of critically ill patients is hindered by a lack of equipment and personnel.

methodsWe used wearable biosensor devices to remotely monitor hospitalized individuals with acute Lassa fever in order to describe vital sign trends that may be associated with clinical outcome and to evaluate the feasibility of this approach in a resource-limited setting.

resultsThe case fatality rate among participants (n = 8) was 62.5%, with a median time from hospital presentation to death of 2 days. Our results show that non-survivors (n = 5) spent a greater proportion of their monitoring period in the age-specific tachycardia range (45.8%) compared to survivors (1.7%), and had lower mean heart rate variability (10 ms) compared to those that survived (59 ms). Due to inconsistent sensor adhesion, as well as Bluetooth and cellular connectivity issues, over 80% of collected vital sign data was discarded for poor quality.

conclusionsReal-time monitoring of vital signs using wearable biosensors may have the potential to identify individuals at increased risk for poor outcomes in Lassa fever by detecting age-specific tachycardia and reductions in heart rate variability. Whether this represents an improvement upon traditional bedside vital sign collection in resource-limited settings is not clear, as a substantial proportion of monitoring data was of poor quality. Technical improvements in sensor connectivity and adhesion are needed to enable widespread use of this device, for both clinical and research purposes.

Identifiers

PMID40646293
PMCPMC12254359

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.