ArticleScientific reports2025
Causal relationships between inflammatory mediators, sleep traits, and cardiac magnetic resonance imaging-derived cardiac phenotypes.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
This study investigated the causal relationships between cytokines, chemokines, neutrophil-related factors, sleep traits, and CMR-derived cardiovascular phenotypes using two-sample Mendelian randomization (MR) analysis. The primary method employed was inverse variance weighted (IVW) analysis, supplemented with MR-Egger and weighted median analyses. We identified 24 significant associations, excluding the SNP rs2001329 related to sleep duration. Notably, CXCL9 showed a strong association with right ventricular peak atrial filling rate (OR = 587.45), while IL-5 was associated with right ventricular stroke volume (OR = 2.45). IL-7 and IL-18 significantly impacted four CMR-derived phenotypes each. Left ventricular ejection fraction was frequently affected by IL-1β, IL-18, CCL2, CXCL9, and NETs. Sensitivity analyses indicated minimal pleiotropy or heterogeneity except for sleep duration. This research highlights crucial cytokines and chemokines that modulate cardiac function through their relationships with cardiovascular phenotypes.
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