Evidence map›Paper›PMID 40646240›Full record

ReviewVirchows Archiv : an international journal of pathology2025

The morphological spectrum of Castleman disease and related disorders: a report from the Lymphoma Workshop of the 22nd Meeting of the European Association of Hematopathology.

Gorana Gasljevic, Arturo Bonometti, Ioannis Anagnostopoulos, Olga Balaguè, Michiel Van den Brand, James R Cook, Camille Laurent, Maurilio Ponzoni, Leticia Quintanilla-Martinez, Birgitta Sander and 1 more

Abstract readReview
In one paragraph

Review in Virchows Archiv : an international journal of pathology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Mesenteric Castleman disease: Two case reports and review of literature.World journal of gastrointestinal surgery · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Gorana GasljevicDepartment of Pathology, Institute of Oncology Ljubljana, Zaloška Cesta 2, 1000, Ljubljana, Slovenia.ORCID http://orcid.org/0000-0002-8332-3627
Arturo BonomettiDepartment of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4, Pieve Emanuele, Milan, 20090, Italy.ORCID http://orcid.org/0000-0003-3258-0727
Ioannis AnagnostopoulosInstitute of Pathology, Julius-Maximilians-Universität Würzburg, Würzburg, Germany.ORCID http://orcid.org/0000-0002-5043-6043
Olga BalaguèHospital Clinic, Pathology Department, Barcelona, Spain.ORCID http://orcid.org/0000-0002-5099-3675
Michiel Van den BrandDepartment of Pathology, Radboud University Medical Center, Nijmegen, The Netherlands.ORCID http://orcid.org/0000-0001-8871-6254
James R CookPathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, OH, US.ORCID http://orcid.org/0000-0003-0456-8085
Camille LaurentDepartment of Pathology, Institut Universitaire du Cancer-Oncopole de Toulouse CHU Toulouse, Toulouse, France.ORCID http://orcid.org/0000-0002-5375-7512
Maurilio PonzoniAteneo Vita-Salute San Raffaele Milan and Pathology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.ORCID http://orcid.org/0000-0002-0055-325X
Leticia Quintanilla-MartinezInstitute for Pathology and Neuropathology, Eberhard-Karls-University of Tübingen and Comprehensive Cancer Center, University Hospital Tübingen, Tübingen, Germany.ORCID http://orcid.org/0000-0001-7156-5365
Birgitta SanderDepartment of Laboratory Medicine, Division of Pathology, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden.ORCID http://orcid.org/0000-0002-1214-1340
Stefan DirnhoferInstitute of Medical Genetics and Pathology, University Hospital Basel, University of Basel, Basel, Switzerland. stefan.dirnhofer@usb.ch.ORCID http://orcid.org/0009-0008-5250-3159

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Castleman disease (CD) is an intriguing and complicated group of local and systemic disorders mainly affecting lymph nodes with heterogeneous presentation and therapeutic needs. These disorders were the topic of Session 1 of the Lymphoma Workshop at the 2024 EA4HP in Dubrovnik, Croatia. In this report, we summarize the features of the 85 submitted cases and review the differential diagnosis, pitfalls, and advances for all CD subtypes. Specifically, the molecular landscape of unicentric CD and its relationship with follicular dendritic cell proliferations and indolent T-lymphoblastic proliferation will be discussed. The spectrum of idiopathic multicentric CD (MCD), TAFRO syndrome, as well as the clinical and histopathological peculiarities of POEMS-CD, is reviewed. Cases of Kaposi sarcoma-associated herpesvirus/human herpesvirus 8 (KSHV/HHV8) + MCD were the most complicated and well demonstrated the difficulties and overlaps in the differential diagnosis of KSHV/HHV8 + lymphoproliferative disorders. Finally, the important topic of CD mimickers will be addressed, demonstrating how the integration of clinical, laboratory, histopathological, and molecular data is mandatory to confirm a diagnosis of CD and how to distinguish it from the many neoplastic, autoimmune, and infective mimickers.

Indexed as

Castleman DiseaseLymph NodesLymphomaDiagnosis, DifferentialHerpesvirus 8, HumanHumansLymphoproliferative DisordersCastleman diseaseCD-mimickersIdiopathic multicentric Castleman diseaseKSHV/HHV8-associated lymphoproliferative disordersPOEMS syndromeTAFRO syndrome

Identifiers

PMID40646240
PMCPMC12391218

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.