Evidence map›Paper›PMID 40646135›Full record

ArticleLeukemia2025

Ontogeny-specific induction of the KMT2A::AFF1-fusion drives development of a distinct CD24 positive pre-leukemic state.

Ariana S Calderón, Roshanak Ghazanfari, Zahra Masoumi, Shabnam Kharazi, Sara Palo, Stefan Lang, Kristijonas Žemaitis, Mohamed Eldeeb, Agatheeswaran Subramaniam, Shamit Soneji and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Leukemia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Ariana S CalderónDivision of Molecular Hematology, Lund Stem Cell Center, Lund University, Lund, Sweden.ORCID 0000-0001-6271-6256
Roshanak GhazanfariDivision of Molecular Hematology, Lund Stem Cell Center, Lund University, Lund, Sweden.
Zahra MasoumiDivision of Molecular Hematology, Lund Stem Cell Center, Lund University, Lund, Sweden.
Shabnam KharaziDivision of Molecular Hematology, Lund Stem Cell Center, Lund University, Lund, Sweden.
Sara PaloDivision of Molecular Hematology, Lund Stem Cell Center, Lund University, Lund, Sweden.
Stefan LangDivision of Molecular Hematology, Lund Stem Cell Center, Lund University, Lund, Sweden.ORCID 0000-0002-0854-2328
Kristijonas ŽemaitisDivision of Molecular Medicine and Gene Therapy, Lund Stem Cell Center, Lund University, Lund, Sweden.
Mohamed EldeebDivision of Molecular Hematology, Lund Stem Cell Center, Lund University, Lund, Sweden.ORCID 0000-0002-8636-2189
Agatheeswaran SubramaniamDivision of Molecular Medicine and Gene Therapy, Lund Stem Cell Center, Lund University, Lund, Sweden.ORCID 0000-0003-3966-3875
Shamit SonejiDivision of Molecular Hematology, Lund Stem Cell Center, Lund University, Lund, Sweden.
Ronald W StamPrincess Maxima Center for Pediatric Oncology, Utrecht, The Netherlands.ORCID 0000-0003-4986-1656
David BryderDivision of Molecular Hematology, Lund Stem Cell Center, Lund University, Lund, Sweden. David.bryder@med.lu.se.ORCID 0000-0002-8761-4237
Charlotta BöiersDivision of Molecular Hematology, Lund Stem Cell Center, Lund University, Lund, Sweden. Charlotta.boiers@med.lu.se.ORCID 0000-0002-4876-1218

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Infant Acute Lymphoblastic Leukemia (ALL) driven by the KMT2A::AFF1 onco-fusion is an aggressive, poor prognosis disease with few co-operative mutations. The fusion originates in utero, yet the embryonic initiating steps of disease development remain poorly understood. Here, we present a novel murine KMT2A::AFF1 model, that provides key insights into KMT2A::AFF1 pre-leukemia, relevant to human disease. The model enables precise oncogene induction, and upon targeting hematopoietic stem and progenitor cells (HSPCs) a selective negative impact on proliferation of hematopoietic stem cells (HSCs) was observed, regardless of developmental state during induction. However, a unique CD24

Indexed as

Fetal DiseasesHistone-Lysine N-MethyltransferaseMyeloid-Lymphoid Leukemia ProteinPrecursor Cell Lymphoblastic Leukemia-LymphomaPreleukemiaAnimalsCD24 AntigenFemaleGene Expression Regulation, NeoplasticHematopoietic Stem CellsHumansLeukemia, ExperimentalMiceOncogene Proteins, FusionPregnancyCD24 AntigenHistone-Lysine N-MethyltransferaseMyeloid-Lymphoid Leukemia ProteinOncogene Proteins, Fusion

Identifiers

PMID40646135
PMCPMC12380613

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.