ArticleLeukemia2025
A genome-wide association study identifies an African-specific locus on chromosome 21q22.12 associated with Burkitt lymphoma risk and survival.
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Article in Leukemia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
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Authors and funding
49 authors.
Diptavo Dutta *Integrative Tumor Epidemiology Branch, Division of Cancer Epidemiology & Genetics, National Cancer Institute, Bethesda, MD, USA.ORCID 0000-0002-6634-9040
Mateus H Gouveia *Center for Research on Genomics & Global Health, Division of Intramural Research, National Human Genome Research Institute, Bethesda, MD, USA.ORCID 0000-0001-6711-5265
Bryan R Gorman *Trans-Divisional Research Program, Division of Cancer Epidemiology & Genetics, National Cancer Institute, Bethesda, MD, USA.ORCID 0000-0002-4239-4672
Atuahene Adu-Gyamfi *Division of Cancer Epidemiology & Genetics, Laboratory of Translational Genomics, National Cancer Institute, Bethesda, MD, USA.
Chia-Han LeeDivision of Cancer Epidemiology & Genetics, Laboratory of Translational Genomics, National Cancer Institute, Bethesda, MD, USA.
Martin D OgwangDepartment of Surgery, St. Mary's Hospital, Lacor, Gulu, Uganda.
Patrick KerchanMedical Superintendent's Office, Kuluva Hospital, Arua, Uganda.
Steven J ReynoldsDivision of Intramural Research, National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA.
Constance N TengeDepartment of Pediatrics, Moi University, Eldoret, Kenya.
Pamela A WereEMBLEM Study, Academic Model Providing Access To Healthcare (AMPATH), Moi Teaching and Referral Hospital, Eldoret, Kenya.
Walter N WekesaDepartment of Pathology, Moi University, Eldoret, Kenya.
Robert K TengeDepartment of Surgery, Moi University, Eldoret, Kenya.
Nestory MasaluDepartment of Oncology, Bugando Medical Center, Mwanza, Tanzania.
Esther L KawiraEMBLEM Study, Shirati Health, Education, and Development Foundation, Shirati, Tanzania.
Tobias KinyeraEMBLEM Study, African Field Epidemiology Network, Gulu, Uganda.
Isaac OtimEMBLEM Study, African Field Epidemiology Network, Gulu, Uganda.
Hadijah NabalendeEMBLEM Study, African Field Epidemiology Network, Gulu, Uganda.
Herry DhudhaEMBLEM Study, Shirati Health, Education, and Development Foundation, Shirati, Tanzania.
Bosco CandiaEMBLEM Study, African Field Epidemiology Network, Gulu, Uganda.
Janet AbaruEMBLEM Study, African Field Epidemiology Network, Gulu, Uganda.
Wusheng YanDivision of Cancer Epidemiology & Genetics, Laboratory of Translational Genomics, National Cancer Institute, Bethesda, MD, USA.ORCID 0000-0002-4722-1156
Oscar Florez-VargasDivision of Cancer Epidemiology & Genetics, Laboratory of Translational Genomics, National Cancer Institute, Bethesda, MD, USA.ORCID 0000-0002-4393-2612
Yi XieDivision of Cancer Epidemiology & Genetics, Laboratory of Translational Genomics, National Cancer Institute, Bethesda, MD, USA.
Michelle HoDivision of Cancer Epidemiology & Genetics, Laboratory of Translational Genomics, National Cancer Institute, Bethesda, MD, USA.ORCID 0000-0002-9143-2241
Leona W AyersDepartment of Pathology, Ohio State University, Columbus, OH, USA.ORCID 0009-0005-1281-1198
Kishor BhatiaInfections and Immunoepidemiology Branch, Division of Cancer Epidemiology & Genetics, National Cancer Institute, Bethesda, MD, USA.
James J GoedertInfections and Immunoepidemiology Branch, Division of Cancer Epidemiology & Genetics, National Cancer Institute, Bethesda, MD, USA.
Ruth M PfeifferBiostatistics Branch, Division of Cancer Epidemiology & Genetics, National Cancer Institute, Bethesda, MD, USA.ORCID 0000-0001-7791-2698
Michelle ManningDivision of Cancer Epidemiology & Genetics, Cancer Genomics Research Laboratory, National Cancer Institute, Bethesda, MD, USA.
Amy HutchinsonDivision of Cancer Epidemiology & Genetics, Cancer Genomics Research Laboratory, National Cancer Institute, Bethesda, MD, USA.
Nathan ColeDivision of Cancer Epidemiology & Genetics, Cancer Genomics Research Laboratory, National Cancer Institute, Bethesda, MD, USA.
Wen LuoDivision of Cancer Epidemiology & Genetics, Cancer Genomics Research Laboratory, National Cancer Institute, Bethesda, MD, USA.
Belynda HicksDivision of Cancer Epidemiology & Genetics, Cancer Genomics Research Laboratory, National Cancer Institute, Bethesda, MD, USA.ORCID 0000-0001-8014-4888
George ChagalukaDepartments of Pediatrics and Surgery, University of Malawi, Blantyre, Malawi.
W Thomas JohnstonDepartment of Health Sciences, Epidemiology and Cancer Statistics Group, University of York, York, UK.
Nora MutalimaCancer Epidemiology Unit, University of Oxford, Oxford, UK.
Eric BorgsteinDepartments of Pediatrics and Surgery, University of Malawi, Blantyre, Malawi.
George N LiombaDepartments of Pediatrics and Surgery, University of Malawi, Blantyre, Malawi.
Steven KamizaDepartments of Pediatrics and Surgery, University of Malawi, Blantyre, Malawi.
Nyengo MkandawireDepartments of Pediatrics and Surgery, University of Malawi, Blantyre, Malawi.
Elizabeth M MolyneuxDepartments of Pediatrics and Surgery, University of Malawi, Blantyre, Malawi.
Collins MitamboResearch Department, National Health Sciences Research Committee, Ministry of Health, Lilongwe, Malawi.
Robert NewtonDepartment of Health Sciences, Epidemiology and Cancer Statistics Group, University of York, York, UK.ORCID 0000-0001-6715-9153
Reiner SiebertInstitute of Human Genetics, Ulm University and Ulm University Medical Center, Ulm, Germany.ORCID 0000-0001-7433-3703
Michael DeanDivision of Cancer Epidemiology & Genetics, Laboratory of Translational Genomics, National Cancer Institute, Bethesda, MD, USA.ORCID 0000-0003-2234-0631
Meredith YeagerDivision of Cancer Epidemiology & Genetics, Cancer Genomics Research Laboratory, National Cancer Institute, Bethesda, MD, USA.ORCID 0000-0003-3871-2225
Stephen J ChanockDivision of Cancer Epidemiology & Genetics, National Cancer Institute, Bethesda, MD, USA.ORCID 0000-0002-2324-3393
Ludmila Prokunina-OlssonDivision of Cancer Epidemiology & Genetics, Laboratory of Translational Genomics, National Cancer Institute, Bethesda, MD, USA.ORCID 0000-0002-9622-2091
Sam M MbulaiteyeInfections and Immunoepidemiology Branch, Division of Cancer Epidemiology & Genetics, National Cancer Institute, Bethesda, MD, USA. mbulaits@mail.nih.gov.ORCID 0000-0002-8273-9831
Funding
NCI NIH HHS HHSN261201100007INCI NIH HHS HHSN261201100063CNHLBI NIH HHS HHSN261201100007CU.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) SUpport to SJRU.S. Department of Health & Human Services | NIH | NCI | Division of Cancer Epidemiology and Genetics, National Cancer Institute (National Cancer Institute Division of Cancer Epidemiology and Genetics) 75N910D00024U.S. Department of Health & Human Services | NIH | NCI | Division of Cancer Epidemiology and Genetics, National Cancer Institute (National Cancer Institute Division of Cancer Epidemiology and Genetics) HHSN261201100063C, HHSN261201100007I, 75N910D00024
Abstract
Burkitt lymphoma (BL) is a B-cell malignancy that disproportionately affects children in sub-Saharan Africa. We performed a genome-wide association study (GWAS) in a combined set of 800 childhood cases and 3865 controls in East Africa, controlling for age, sex, country, population-specific principal components, and a genetic relationship matrix. This analysis identified a BL-protective region within chromosome 21q22.12 tagged by the rs111457485-T allele (odds ratio [OR] = 0.57; p = 5.7 × 10
Indexed as
Black PeopleBurkitt LymphomaChromosomes, Human, Pair 21Genetic LociGenetic Predisposition to DiseaseGenome-Wide Association StudyPolymorphism, Single NucleotideAdolescentCase-Control StudiesChildChild, PreschoolCore Binding Factor Alpha 2 SubunitFemaleHumansMalePrognosisCore Binding Factor Alpha 2 Subunit
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.