Evidence map›Paper›PMID 40646074›Full record

ArticleScientific reports2025

Nanocarrier mediated DOX/siRNA targeted co-delivery for synergistic treatment of cutaneous melanoma in outdoor athletes.

Liangping Li, Yanping Ma, Erqing Huang, Qiang Shi, Zhen Ma

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Liangping LiDepartment of Physical Education, Anhui College of Traditional Chinese Medicine, Wuhu, China.
Yanping MaDepartment of Physical Education, Anhui College of Traditional Chinese Medicine, Wuhu, China.
Erqing HuangDepartment of Physical Education, Anhui College of Traditional Chinese Medicine, Wuhu, China.
Qiang ShiDepartment of Physical Education, Anhui College of Traditional Chinese Medicine, Wuhu, China.
Zhen MaDepartment of Physical Education, Wannan Medical College, Wuhu, China. mazhen163WY@163.com.

Funding

Anhui Provincial Philosophy and Social Science Planning Project AHSKZ2018D10Natural Science Research Project of Anhui Higher Education Institutions KJ2020A0869Young and Middle-aged Scientific Research Fund of Wannan Medical College WYRCQD2023025
6 · The paper itself

Abstract

Athletes engaging in long-term and high-intensity outdoor exercise training are at high-risk for cutaneous melanoma (CM). Due to the limitations and side effects of traditional tumor treatment methods, it's difficult for athletes with CM to maintain athletic ability and prolong sport career. Targeted combination therapy based on nanocarriers is currently a promising method for achieving more satisfactory therapeutic effects. Herein, the folate-biotin-quaternized starch nanoparticles (FBqS NPs) were used as a co-loading platform to deliver doxorubicin (DOX) and siRNA

Indexed as

DoxorubicinDrug CarriersMelanomaNanoparticlesRNA, Small InterferingSkin NeoplasmsAthletesCell Line, TumorCell MovementCell ProliferationCutaneous Malignant MelanomaDrug Delivery SystemsFolic AcidHumansReceptor, IGF Type 1DoxorubicinDrug CarriersFolic AcidReceptor, IGF Type 1RNA, Small InterferingAthleteChemotherapeuticsCombination therapyGene drugSkin cancer

Identifiers

PMID40646074
PMCPMC12254362

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.