Microvasculature recovery in lamina cribrosa and peripapillary sclera after glaucoma surgery and its impact on visual field progression.

Hee Jong Shin, Hee Kyung Ryu, Seong Ah Kim, Younhea Jung, Chan Kee Park, Hae-Young Lopilly Park

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Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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6 authors.

Hee Jong ShinDepartment of Ophthalmology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea.

Hee Kyung RyuDepartment of Ophthalmology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea.

Seong Ah KimDepartment of Ophthalmology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea.

Younhea JungDepartment of Ophthalmology, Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea.

Chan Kee ParkDepartment of Ophthalmology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea.

Hae-Young Lopilly ParkDepartment of Ophthalmology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea. lopilly@catholic.ac.kr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study investigates vessel density (VD) changes in the lamina cribrosa (LC) and peripapillary sclera (PPS) after glaucoma surgery and their association with visual field (VF) progression. Primary open-angle glaucoma patients undergoing surgery for uncontrolled intraocular pressure (IOP) at Seoul St. Mary's Hospital were included. Optical coherence tomography angiography (OCT-A) assessed VD changes in the LC and PPS one month post-surgery. VF progression was evaluated using mean deviation (MD) values from serial VF tests over six months. Of 80 enrolled eyes, 74 were analyzed. Laminar VD recovery occurred in 12 eyes (16.2%), with a 21.92% ± 7.37% increase, linked to shorter axial length (P = 0.005), thinner corneal thickness (P = 0.016), and less PPS VD change (P < 0.001). PPS VD recovery occurred in 14 eyes (18.9%), with an 18.50% ± 7.28% increase, associated with younger age (P = 0.043), longer axial length (P = 0.010), and lower preoperative PPS VD (P < 0.001). Multivariate analysis showed that both laminar and PPS VD recovery significantly reduced VF progression risk (P < 0.001). VD recovery, particularly in the LC, predicts better glaucoma outcomes. The distinct responses of LC and PPS to IOP reduction highlight the need to consider individual anatomical factors in glaucoma management.

Indexed as

GlaucomaGlaucoma, Open-AngleMicrovesselsOptic DiskScleraVisual FieldsAgedDisease ProgressionFemaleHumansIntraocular PressureMaleMiddle AgedTomography, Optical CoherenceGlaucoma surgeryLamina cribrosaMicrovasculature recoveryPeripapillary sclera

Identifiers

PMID40646033

DOI10.1038/s41598-025-08205-w

PMCPMC12254377

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.