ArticleNature communications2025
A tactile discrimination task to study neuronal dynamics in freely-moving mice.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Thalamocortical bursts encode reward contingencies and drive associative learning.Nature communications · 2026Article
- The role of transthalamic pathways in perception.Communications biology · 2026Review
- Soft bionic actuation explains the functional role of whisking in seal whisker sensing.Npj flexible electronics · 2026Article
- Layer 5 myelination gates corticothalamic coincidence detection.Nature communications · 2025Article
- Syntalos: a software for precise synchronization of simultaneous multi-modal data acquisition and closed-loop interventions.Nature communications · 2025Article
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Authors and funding
12 authors.
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Abstract
Sensory discrimination tasks are valuable tools to study neuronal mechanisms of perception and learning, yet most rodent paradigms rely on head fixation. Here, we present a whisker-dependent go/no-go discrimination task for freely moving mice, compatible with high-resolution electrophysiology and calcium imaging. Adult male mice rapidly learned to discriminate aperture widths while foraging on a linear platform, enabling investigations of tactile thresholds, rule reversals, and behavioral flexibility. Neural recordings revealed distributed tactile coding across the thalamocortical system, with units tuned to both sensory and motor features, including whisking, head angle, and spatial position. Aperture selectivity emerged in the barrel cortex during learning, and cortical lesions impaired performance, highlighting cortical involvement in learning and task execution. The setup is modular, automated, and supports simultaneous recordings and imaging aligned to naturalistic behavior. This platform provides a powerful tool to dissect sensory processing and learning in ethologically relevant conditions.
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