ArticleNature communications2025
Direct entorhinal control of CA1 temporal coding.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed.
- Instructive signals drive learning through behavioral timescale synaptic plasticity in the hippocampus and beyond.Current research in neurobiology · 2026Article
- Medial entorhinal-hippocampal desynchronization parallels the emergence of memory impairment in a mouse model of Alzheimer's disease pathology.Cell reports · 2026Article
- The emergence of a novel CA1 spatial map requires direct entorhinal input.bioRxiv : the preprint server for biology · 2026Article
- Coordinating Cognition: The Entorhinal Cortex in Mnemonic, Temporal and Spatial Representation.Cells · 2026Review
- Functional transition of CA2 pyramidal neurons along the proximodistal axis determines resonance frequency preference.Scientific reports · 2026Article
- Brain region-specific gain modulation of place cells by VIP neurons.Nature communications · 2025Article
- Distinct changes to hippocampal and medial entorhinal circuits emerge across the progression of cognitive deficits in epilepsy.Cell reports · 2025Article
- Software and pipelines for registration and analyses of rodent brain image data in reference atlas space.Frontiers in neuroinformatics · 2025Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Theta sequences of hippocampal activity supports planning and prediction, and in CA1 they are shaped by CA3 and entorhinal (layer III) inputs. We targeted entorhinal inputs with highly specific optogenetic inhibition, leaving the remaining circuit intact. While CA1 spatial coding properties were largely unaffected, the slope and range of theta phase precession were impaired. Surprisingly, theta sequences were strengthened. These results suggest that sequence organization is not a simple consequence of precession and depends on circuit-level dynamics across the trisynaptic circuit, while direct entorhinal inputs may act as a supervisory signal driving learning and representational updates.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.