ArticleThe journal of prevention of Alzheimer's disease2025
Associations of cardiovascular health assessed by life's crucial 9 with incident cardiovascular disease and dementia: A prospective cohort study.
Article in The journal of prevention of Alzheimer's disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed.
- Associations of cardiovascular health and genetic susceptibility with incident psoriatic arthritis: findings from two cohort studies.Clinical rheumatology · 2026Article
- LifeZhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2026Article
- Association of the cumulative modified life's Essential 8 score with cognitive change: Results from two longitudinal cohorts.The journal of prevention of Alzheimer's disease · 2026Article
- Associations between Life's Crucial 9 and severity, all-cause mortality, and cardiovascular mortality in individuals with cardiovascular-kidney-metabolic syndrome: the mediating role of phenotypic age acceleration.Frontiers in nutrition · 2025Article
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15 authors.
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Abstract
backgroundThe associations of the renewed cardiovascular health (CVH) assessed by Life's Crucial 9 (LC9), which consisted of Life's Essential 8 (LE8) and psychological health, with incident cardiovascular disease (CVD) and dementia remained unexplored.
objectivesThis study aims to investigate the associations and determine whether LC9 has a higher discrimination ability than LE8 in predicting incident CVD and dementia. DESIGN, SETTING, AND
participantsThis study was a prospective population-based cohort study using data from the UK Biobank. MEASUREMENTS: LC9 was assessed as American Heart Association recommended. Incident CVD and dementia were based on self-reported data, hospital inpatient records, and death register records.
resultsOf 289,649 included participants, 137,480 (47.5 %) were male, and the mean age was 56.6 ± 8.1 years. Compared with participants having low LC9, those having moderate or high LC9 had lower risks of incident CVD (moderate: 0.46 [0.43-0.48]; high: 0.25 [0.23-0.27]; p for trend <0.001) and dementia (moderate: 0.57 [0.50-0.64]; high: 0.45 [0.39-0.52]; p for trend <0.001) after multivariate adjustment. Both the LE8 and LC9 achieved good discriminative performance for incident CVD (LE8 Harrell C-statistic= 0.7138 vs. LC9 Harrell C-statistic=0.7144, p = 0.136); the net reclassification improvement was estimated at 0.07 % (p = 0.749), and integrated discrimination improvement was estimated at 0.009 (p < 0.001). The results for dementia showed similar patterns. CONCLUSIONS AND RELEVANCE: Optimal LC9 was associated with lower risks of incident CVD and dementia. Although psychological health is essential for preventing CVD and dementia, including it into CVH's evaluation criteria did not significantly improve CVH's predictive performance.
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