ArticleJACC. Case reports2025
Interaction Between Cardiogenic Shock and Hypothyroidism in Critical Care Medicine.
Article in JACC. Case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
A 44-year-old male smoker presented with progressive dyspnea over 10 days. Admitted while in cardiogenic shock, the patient had severe dyspnea, hypoxia, and hemodynamic instability. Diagnostics showed diffuse lung opacities, bilateral effusions, severe left ventricular dysfunction (ejection fraction [EF], 10%-15%), and a large pericardial effusion. Initial treatments with inotropes and intra-aortic balloon pump failed, necessitating veno-arterial extracorporeal membrane oxygenation and a pericardial window. Lab results confirmed severe hypothyroidism (thyroid stimulating hormone, 76 μU/mL, free T4 0.1 ng/dL). Treatment with intravenous levothyroxine and steroids stabilized the patient, allowing extracorporeal membrane oxygenation weaning by day 10 and significant improvement in cardiac function over 45 days. Hypothyroidism is a rare but reversible cause of cardiogenic shock, impairing myocardial function via reduced contractility and vascular resistance. Early diagnosis and treatment with hormonal therapy and mechanical support are crucial.
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