Evidence map›Paper›PMID 40645654›Full record

ArticleBMJ mental health2025

Association of hyperactivity-impulsivity and inattention symptom profiles with suicide attempt: an 18-year population-based cohort study.

Michel Spodenkiewicz, Ayla Inja, Samuele Cortese, Cedric Galera, Isabelle Ouellet-Morin, Sylvana M Côté, Michel Boivin, Frank Vitaro, Mara Brendgen, Ginette Dionne and 5 more

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Article in BMJ mental health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

15 authors.

Michel Spodenkiewicz *McGill Group for Suicide Studies, Douglas Mental Health University Institute, Department of Psychiatry, McGill University, Montreal, Quebec, Canada.
Ayla Inja *McGill Group for Suicide Studies, Douglas Mental Health University Institute, Department of Psychiatry, McGill University, Montreal, Quebec, Canada.
Samuele CorteseDevelopmental EPI (Evidence synthesis, Prediction, Implementation) Lab, Centre for Innovation in Mental Health, School of Psychology, Faculty of Environmental and Life Sciences, University of Southamptopn, Southampton, UK.ORCID 0000-0001-5877-8075
Cedric GaleraINSERM, Bordeaux Population Health Center, Bordeaux II University, Talence, France.
Isabelle Ouellet-MorinDepartment of Criminology, Université de Montreal, Montreal, Quebec, Canada.
Sylvana M CôtéCentre de recherche Azrieli, CHU Sainte-Justine, Montreal, Quebec, Canada.
Michel BoivinSchool of Psychology, Laval University, Québec City, Quebec, Canada.
Frank VitaroCentre de recherche Azrieli, CHU Sainte-Justine, Montreal, Quebec, Canada.
Mara BrendgenDepartment of Psychology, Université du Québec à Montréal, Montreal, Quebec, Canada.
Ginette DionneSchool of Psychology, Laval University, Québec City, Quebec, Canada.
Johanne RenaudMcGill Group for Suicide Studies, Douglas Mental Health University Institute, Department of Psychiatry, McGill University, Montreal, Quebec, Canada.
Richard E TremblayCentre de recherche Azrieli, CHU Sainte-Justine, Montreal, Quebec, Canada.
Gustavo TureckiMcGill Group for Suicide Studies, Douglas Mental Health University Institute, Department of Psychiatry, McGill University, Montreal, Quebec, Canada.
Marie-Claude GeoffroyMcGill Group for Suicide Studies, Douglas Mental Health University Institute, Department of Psychiatry, McGill University, Montreal, Quebec, Canada.
Massimilano OrriMcGill Group for Suicide Studies, Douglas Mental Health University Institute, Department of Psychiatry, McGill University, Montreal, Quebec, Canada massimiliano.orri@mcgill.ca.ORCID 0000-0003-1389-2610

Funding

UK Department of Health and Social Care NIHR128472UK Department of Health and Social Care NIHR130077UK Department of Health and Social Care NIHR203035UK Department of Health and Social Care NIHR203684
6 · The paper itself

Abstract

backgroundAttention-deficit/hyperactivity disorder (ADHD) symptomatology in childhood is associated with a high risk of suicide attempt later in life. However, symptom presentation in ADHD is heterogeneous, and little is known about how suicide risk varies according to different profiles of ADHD symptoms and sex.

objectiveThe aim was to investigate the longitudinal associations between childhood profiles of ADHD symptoms (ie, hyperactivity-impulsivity and inattention) and youth suicide attempt in males and females, separately.

methodsThis population-based cohort study used data from three longitudinal cohorts: the Quebec Longitudinal Study of Child Development (QLSCD), the Quebec Longitudinal Study of Kindergarten Children (QLSKC) and the Quebec Newborn Twin Study (QNTS) for a total of 4399 participants (1490 from the QLSCD, 2134 from the QLSKC and 775 from the QNTS; 50% females) followed up from ages 6-23 years. Symptoms of hyperactivity-impulsivity and inattention were assessed by teachers five times from ages 6-12 years. Suicide attempt in adolescence and young adulthood (by age 23) was self-reported. Multitrajectory modelling was used to identify profiles of ADHD symptoms, and regression analysis was used to test their association with suicide attempt, adjusting for childhood socioeconomic and clinical characteristics.

findingsWe identified four ADHD symptom profiles with distinct associations with suicide attempt for males and females. Compared with those with persistently low symptoms, females with persistently high inattention and hyperactivity-impulsivity (OR: 2.54, CI 1.39 to 4.63) or high inattention and low hyperactivity-impulsivity (OR: 1.81, CI 1.21 to 2.70) were at higher risk of suicide attempt, while, among males, only those with decreasing hyperactivity-impulsivity and inattention over time (OR: 2.23, CI 1.20 to 4.13) were at higher risk of suicide attempt.

conclusionsRisk of suicide attempt in children with ADHD symptoms varies according to both symptom profile and sex, the highest risk being for females with high inattention symptoms (with or without hyperactivity), and males with decreasing symptoms. CLINICAL IMPLICATIONS: Taking into account differences in both sex and ADHD symptoms profile may be relevant to more accurately identify and manage suicide risk in individuals with high ADHD symptoms, though caution is needed when generalising our population-based findings to clinical populations.

Indexed as

Attention Deficit Disorder with HyperactivityImpulsive BehaviorSuicide, AttemptedAdolescentChildCohort StudiesFemaleHumansLongitudinal StudiesMaleQuebecRisk FactorsSex FactorsYoung AdultChild & adolescent psychiatrySuicide & self-harm

Identifiers

PMID40645654
PMCPMC12248219

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