SynthesisBMJ open2025
Anxiety and depression in cardiac amyloidosis: a systematic review.
Synthesis in BMJ open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesCardiac amyloidosis (CA) is a rare and underdiagnosed disease associated with a high mortality rate. Although, in the last decade, there has been increasing attention in the literature to the relationship between CA and psychological distress in patients, the evidence on this association has not yet been systematised. Therefore, this study aims to fill this gap.
designFollowing the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, a systematic review was conducted. DATA SOURCES: PubMed, ScienceDirect, Scopus and Web of Science were searched, with the last update conducted on 23 September 2024, and no time restrictions were applied. ELIGIBILITY CRITERIA: Studies had to meet the following inclusion criteria to be included: (1) original quantitative research; (2) published in peer-reviewed journals written in English; (3) explore and report the relationship between CA and psychological distress or compare a clinical group with a control group and (4) investigate psychological distress through reliable and validated measures. DATA EXTRACTION AND SYNTHESIS: One author extracted the data, which was then double-checked by another, and data were reported both in tabular and textual form. The included studies were critically evaluated using the Appraisal Tool for Cross-Sectional Studies.
resultsThrough the research process, a total of 14 articles were selected. The quality assessment scores ranged from 12 to 18 (M=16.21±1.42). Overall, the results underline a significant presence of psychological distress in patients with CA. Moreover, while disease severity was not found to be associated with psychological distress in CA patients in all studies considered, more heterogeneous results emerged regarding the association between the severity of cardiac symptoms and psychological distress.
conclusionsResults suggest that psychological distress is an important aspect to be considered when dealing with CA patients. Integrating psychological assessment and support may improve patient outcomes by reducing disease burden and enhancing treatment adherence. PROSPERO REGISTRATION NUMBER: CRD42023446913.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.