Evidence map›Paper›PMID 40645371›Full record

ArticleContemporary clinical trials2025

Telehealth engagement and treatment strategies for adults living with alcohol use disorder: A sequential multiple assignment randomized trial protocol.

Erin E Bonar, Kelley Kidwell, Lyndsay Chapman, Maureen A Walton, Kai Zheng, Carrie Bourque, Deborah Manderachia, Olivia E Robinson, Alaa A Eissa, Shayla E Dailey and 7 more

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Contemporary clinical trials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05594238 (Leveraging Virtual Care Strategies to Improve Access and Treatment for Individuals With Alcohol Use Disorders), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05594238 naactive not recruitingnot on this map

Leveraging Virtual Care Strategies to Improve Access and Treatment for Individuals With Alcohol Use Disorders (AUD)

TypeinterventionalSponsorUniversity of MichiganRan2023 to 2027Enrolled362ConditionsAlcohol Use DisorderArmsTelephone Engagement, Portal Engagement, MI-CBT
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Erin E BonarDepartment of Psychiatry, University of Michigan, North Campus Research Complex, 2800 Plymouth Rd. Building 16, Ann Arbor, MI 48109, USA; Michigan Innovations in Addiction Care through Research & Education, University of Michigan, North Campus Research Complex, 2800 Plymouth Rd. Building 16, Ann Arbor, MI 48109, USA; Injury Prevention Center, University of Michigan, North Campus Research Complex, 2800 Plymouth Rd. Building 10, Ann Arbor, MI 48109, USA. Electronic address: erinbona@med.umich.edu.
Kelley KidwellDepartment of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA.
Lyndsay ChapmanDepartment of Psychiatry, University of Michigan, North Campus Research Complex, 2800 Plymouth Rd. Building 16, Ann Arbor, MI 48109, USA.
Maureen A WaltonDepartment of Psychiatry, University of Michigan, North Campus Research Complex, 2800 Plymouth Rd. Building 16, Ann Arbor, MI 48109, USA; Michigan Innovations in Addiction Care through Research & Education, University of Michigan, North Campus Research Complex, 2800 Plymouth Rd. Building 16, Ann Arbor, MI 48109, USA; Injury Prevention Center, University of Michigan, North Campus Research Complex, 2800 Plymouth Rd. Building 10, Ann Arbor, MI 48109, USA; Addiction Center, Department of Psychiatry, University of Michigan, North Campus Research Complex, 2800 Plymouth Rd. Building 16, Ann Arbor, MI 48109, USA.
Kai ZhengDepartment of Psychiatry, University of Michigan, North Campus Research Complex, 2800 Plymouth Rd. Building 16, Ann Arbor, MI 48109, USA; Department of Informatics, Donald Bren School of Information and Computer Sciences, University of California, Irvine, Donald Bren Hall, Irvine, CA 92697, USA.
Carrie BourqueDepartment of Psychiatry, University of Michigan, North Campus Research Complex, 2800 Plymouth Rd. Building 16, Ann Arbor, MI 48109, USA.
Deborah ManderachiaDepartment of Psychiatry, University of Michigan, North Campus Research Complex, 2800 Plymouth Rd. Building 16, Ann Arbor, MI 48109, USA; Center for Clinical Management Research, VA Ann Arbor Healthcare System, North Campus Research Complex, 2800 Plymouth Rd Bldg 16, Ann Arbor, MI 48109, USA.
Olivia E RobinsonDepartment of Psychiatry, University of Michigan, North Campus Research Complex, 2800 Plymouth Rd. Building 16, Ann Arbor, MI 48109, USA.
Alaa A EissaDepartment of Psychiatry, University of Michigan, North Campus Research Complex, 2800 Plymouth Rd. Building 16, Ann Arbor, MI 48109, USA.
Shayla E DaileyDepartment of Psychiatry, University of Michigan, North Campus Research Complex, 2800 Plymouth Rd. Building 16, Ann Arbor, MI 48109, USA; Center for Clinical Management Research, VA Ann Arbor Healthcare System, North Campus Research Complex, 2800 Plymouth Rd Bldg 16, Ann Arbor, MI 48109, USA.
Frank DoleckiDepartment of Psychiatry, University of Michigan, North Campus Research Complex, 2800 Plymouth Rd. Building 16, Ann Arbor, MI 48109, USA.
Olivia D TeasdaleDepartment of Psychiatry, University of Michigan, North Campus Research Complex, 2800 Plymouth Rd. Building 16, Ann Arbor, MI 48109, USA.
Alanah NanCoffDepartment of Psychiatry, University of Michigan, North Campus Research Complex, 2800 Plymouth Rd. Building 16, Ann Arbor, MI 48109, USA.
Emily E ChizekDepartment of Psychiatry, University of Michigan, North Campus Research Complex, 2800 Plymouth Rd. Building 16, Ann Arbor, MI 48109, USA; Center for Clinical Management Research, VA Ann Arbor Healthcare System, North Campus Research Complex, 2800 Plymouth Rd Bldg 16, Ann Arbor, MI 48109, USA.
Tyleah S TynerDepartment of Psychiatry, University of Michigan, North Campus Research Complex, 2800 Plymouth Rd. Building 16, Ann Arbor, MI 48109, USA.
Alesha L MillerDepartment of Psychiatry, University of Michigan, North Campus Research Complex, 2800 Plymouth Rd. Building 16, Ann Arbor, MI 48109, USA; Center for Clinical Management Research, VA Ann Arbor Healthcare System, North Campus Research Complex, 2800 Plymouth Rd Bldg 16, Ann Arbor, MI 48109, USA.
Lewei Allison LinDepartment of Psychiatry, University of Michigan, North Campus Research Complex, 2800 Plymouth Rd. Building 16, Ann Arbor, MI 48109, USA; Michigan Innovations in Addiction Care through Research & Education, University of Michigan, North Campus Research Complex, 2800 Plymouth Rd. Building 16, Ann Arbor, MI 48109, USA; Department of Informatics, Donald Bren School of Information and Computer Sciences, University of California, Irvine, Donald Bren Hall, Irvine, CA 92697, USA; Center for Clinical Management Research, VA Ann Arbor Healthcare System, North Campus Research Complex, 2800 Plymouth Rd Bldg 16, Ann Arbor, MI 48109, USA.

Funding

Leveraging virtual care strategies to improve access and treatment for individuals with alcohol use disordersR01AA029808 · NIAAA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Erin E. Bonar, Lewei Allison Lin · 2022 to 2026
$3.4M
EPA EP-C-18-008NIAAA NIH HHS R01 AA029808
6 · The paper itself

Abstract

backgroundTreatment rates for alcohol use disorder (AUD) among adults in the United States (US) are low. Healthcare systems with electronic health records (EHRs) could identify those experiencing AUD and conduct outreach followed by treatment to reduce drinking and/or AUD symptoms. Here, we describe the protocol for a sequential, multiple assignment, randomized trial (SMART) of multiple technology-driven adaptive interventions (ADIs) to increase AUD care and improve outcomes among adults within a large healthcare system.

methodsWe plan to enroll 400 adults in this two-stage SMART. Potential participants identified by alcohol indicators in the EHR are screened for eligibility criteria: current drinking, AUD, and lack of current AUD psychotherapy treatment. Participants are randomized to Stage 1 interventions: 1 brief motivational interviewing (MI)-focused phone session, or 4 weeks of interactive therapeutic messaging delivered via a patient-portal like system. Non-responders at a 4-week post-test are re-randomized to an enhanced dose of their Stage 1 intervention (i.e., additional phone session or 4 weeks of messaging) or to an 8-session MI-Cognitive Behavioral Therapy (MI-CBT) protocol via video/phone. Outcomes (e.g., drinking, treatment utilization) are measured at 4-, 8-, and 12-months post-enrollment.

conclusionsThis innovative SMART evaluates critical technology-driven ADI strategies within an AUD engagement and care model. We will identify the most effective initial strategy (phone session vs. portal messaging) and, among non-responders, we will assess the most effective follow-up strategy (additional Stage 1 dose vs. MI-CBT). Outcomes will inform the utility of scalable ADIs to engage and improve outcomes for patients with untreated AUD.

trial registrationClinicalTrials.gov #NCT05594238. University of Michigan HUM00210546. NCT registration: NCT05594238.

Indexed as

AlcoholismMotivational InterviewingTelemedicineAdultElectronic Health RecordsFemaleHumansMaleRandomized Controlled Trials as TopicUnited StatesAdaptive interventionsAlcohol use disorderCognitive behavioral therapyMotivational interviewingTelehealth

Identifiers

PMID40645371
PMCPMC12314782

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.