Evidence map›Paper›PMID 40645267›Full record

ArticleEnvironmental pollution (Barking, Essex : 1987)2025

Maternal serum and placental metabolomes in association with prenatal exposure to per- and polyfluoroalkyl substances and their relevance to child neurodevelopment in an ASD-enriched cohort.

Jeong Weon Choi, Mariana Parenti, Carolyn M Slupsky, Daniel J Tancredi, Rebecca J Schmidt, Hyeong-Moo Shin

Abstract read
In one paragraph

Article in Environmental pollution (Barking, Essex : 1987), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jeong Weon ChoiDepartment of Environmental Science, Baylor University, Waco, TX, USA. Electronic address: JeongWeon_Choi@baylor.edu.
Mariana ParentiDepartment of Nutrition, University of California, Davis, Davis, CA, USA.
Carolyn M SlupskyDepartment of Nutrition, University of California, Davis, Davis, CA, USA; Department of Food Science and Technology, University of California, Davis, Davis, CA, USA.
Daniel J TancrediDepartment of Pediatrics, School of Medicine, University of California, Davis, Davis, CA, USA.
Rebecca J SchmidtDepartment of Public Health Sciences, University of California, Davis, Davis, CA, USA; MIND Institute, Sacramento, CA, USA.
Hyeong-Moo ShinDepartment of Environmental Science, Baylor University, Waco, TX, USA.

Funding

UC Davis Center for Children's Environmental Health (CCEH)P01ES011269 · NIEHS · UNIVERSITY OF CALIFORNIA DAVIS · PI VAN DE WATER, JUDY A. · 2001 to 2018
$12.5M
Research Project: Pathologic Significance of Maternal AutoantibodiesP50HD103526 · NICHD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI LEONARD J. ABBEDUTO, Melissa Dawn Bauman · 2020 to 2026
$9.7M
Autism Risk, Prenatal Environmental Exposures, and Pathophysiologic MarkersR01ES020392 · NIEHS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI HERTZ-PICCIOTTO, IRVA, OZONOFF, SALLY · 2011 to 2015
$9.0M
Rodent Behavior CoreU54HD079125 · NICHD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI OZONOFF, SALLY · 2013 to 2019
$8.5M
Environmental Influence on Infant Microbiome Development and ASD SymptomsR01ES028089 · NIEHS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI HERTZ-PICCIOTTO, IRVA, MILLS, DAVID ANDREW · 2016 to 2020
$3.6M
BUILDS MARBLES: Biorepository Upkeep and Infrastructure for Longitudinal Data Sharing for MARBLESR24ES028533 · NIEHS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Brittany D. Chambers Butcher, Rebecca Jean Schmidt · 2017 to 2026
$2.3M
BUILDS MARBLES: Biorepository Upkeep and Infrastructure for Longitudinal Data Sharing for MARBLESU24ES028533 · NIEHS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CHAMBERS BUTCHER, BRITTANY D., SCHMIDT, REBECCA JEAN · 2023 to 2025
$1.2M
Exposure to Perfluorinated Compounds and Risk for Autism Spectrum DisordersR21ES028131 · NIEHS · UNIVERSITY OF TEXAS ARLINGTON · PI SHIN, HYEONG-MOO · 2017 to 2018
$436k
NICHD NIH HHS P50 HD103526NICHD NIH HHS U54 HD079125NIEHS NIH HHS P01 ES011269NIEHS NIH HHS R01 ES020392NIEHS NIH HHS R01 ES028089NIEHS NIH HHS R21 ES028131NIEHS NIH HHS R24 ES028533NIEHS NIH HHS U24 ES028533
6 · The paper itself

Abstract

Prenatal exposure to per- and polyfluoroalkyl substances (PFAS) has been linked to altered neurodevelopment in children, but the contribution of maternal metabolic disruption to this relationship remains unclear. We investigated associations between prenatal PFAS exposure, maternal metabolism, and child neurodevelopment. We analyzed 172 mother-child pairs from the MARBLES (Markers of Autism Risk in Babies-Learning Early Signs) cohort. Nine PFAS were measured in maternal serum collected during pregnancy. Metabolites were quantified in third-trimester serum and placental tissue using proton nuclear magnetic resonance (

Indexed as

Autism Spectrum DisorderEnvironmental PollutantsFluorocarbonsMaternal ExposureMetabolomePlacentaPrenatal Exposure Delayed EffectsAdultAlkanesulfonic AcidsChild DevelopmentChild, PreschoolCohort StudiesFemaleHumansMalePregnancyAlkanesulfonic AcidsEnvironmental PollutantsFluorocarbons(1)H-NMRChild neurodevelopmentMetabolitesPFASPlacentaPrenatal exposureSerum

Identifiers

PMID40645267
PMCPMC12328018

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.