Evidence map›Paper›PMID 40645161›Full record

ArticleHearing research2025

Low level of expression of known deafness genes Kcne1, Kcnj10 or Col4a3 is sufficient to maintain hearing in mice.

Darcey A Kirwin, Nina Treder, Elisa Martelletti, Daniel R Pentland, Rechal Kumar, Neil J Ingham, Karen P Steel

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Hearing research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Darcey A KirwinWolfson Sensory, Pain and Regeneration Centre, King's College London, London SE1 1UL, UK.
Nina TrederWolfson Sensory, Pain and Regeneration Centre, King's College London, London SE1 1UL, UK.
Elisa MartellettiWolfson Sensory, Pain and Regeneration Centre, King's College London, London SE1 1UL, UK.
Daniel R PentlandWolfson Sensory, Pain and Regeneration Centre, King's College London, London SE1 1UL, UK.
Rechal KumarWolfson Sensory, Pain and Regeneration Centre, King's College London, London SE1 1UL, UK.
Neil J InghamWolfson Sensory, Pain and Regeneration Centre, King's College London, London SE1 1UL, UK.
Karen P SteelWolfson Sensory, Pain and Regeneration Centre, King's College London, London SE1 1UL, UK. Electronic address: karen.steel@kcl.ac.uk.

Funding

Wellcome TrustWellcome Trust 221769/Z/20/Z
6 · The paper itself

Abstract

Kcne1, Kcnj10 and Col4a3 are all expressed in the stria vascularis where they serve critical roles in generating the endocochlear potential. Mutations in any of these three genes are linked to human deafness syndromes for which there are currently no treatments. Here, the hearing ability of three mouse lines carrying mutant alleles in these genes (Kcne1

Indexed as

Collagen Type IVDeafnessHearingPotassium Channels, Inwardly RectifyingPotassium Channels, Voltage-GatedAnimalsAuditory ThresholdDisease Models, AnimalEvoked Potentials, Auditory, Brain StemKcnj10 ChannelMiceMice, Inbred C57BLMutationPhenotypeStria VascularisCollagen Type IVKcne1 protein, mouseKcnj10 ChannelPotassium Channels, Inwardly RectifyingPotassium Channels, Voltage-GatedHearing lossMouse geneticsStria vascularis

Identifiers

PMID40645161
PMCPMC7619435

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.