Evidence map›Paper›PMID 40644723›Full record

ArticleJournal of neurosurgery2025

An opportune time for targeted brain arteriovenous malformation therapy.

Andrew T Hale, Pazhanichamy Kalailingam, Adam J Kundishora, Benjamin C Reeves, Priscilla K Brastianos, Helen A Shih, Rakesh K Jain, MingMing Ning, Christopher J Stapleton, Aman B Patel and 6 more

Abstract read
In one paragraph

Article in Journal of neurosurgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Towards precision medicine for brain arteriovenous malformations.The Journal of clinical investigation · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Andrew T Hale1Department of Neurosurgery, University of Alabama at Birmingham, Alabama.
Pazhanichamy Kalailingam3Center for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts.
Adam J Kundishora4Division of Neurosurgery, Children's Hospital of Philadelphia, Pennsylvania.
Benjamin C Reeves5Department of Neurosurgery, Barrow Neurological Institute, Phoenix, Arizona.
Priscilla K Brastianos6Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts.
Helen A Shih7Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts.
Rakesh K Jain7Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts.
MingMing Ning8Department of Neurology, Harvard Medical School and Massachusetts General Hospital, Boston, Massachusetts.
Christopher J Stapleton10Department of Neurosurgery, Harvard Medical School and Massachusetts General Hospital, Boston, Massachusetts.
Aman B Patel10Department of Neurosurgery, Harvard Medical School and Massachusetts General Hospital, Boston, Massachusetts.
Edward R Smith11Cerebrovascular Surgery and Interventions Center, Boston Children's Hospital, Boston, Massachusetts.
Paul H Chapman10Department of Neurosurgery, Harvard Medical School and Massachusetts General Hospital, Boston, Massachusetts.
James D Rabinov10Department of Neurosurgery, Harvard Medical School and Massachusetts General Hospital, Boston, Massachusetts.
Benjamin P Kleinstiver3Center for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts.
Patricia L Musolino3Center for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts.
Kristopher T Kahle10Department of Neurosurgery, Harvard Medical School and Massachusetts General Hospital, Boston, Massachusetts.

Funding

Human Genetics and Molecular Mechanisms of Vein of Galen Aneurysmal MalformationR01NS117609 · NINDS · YALE UNIVERSITY · PI Titus Jonathon Boggon, Kristopher T. Kahle · 2020 to 2026
$3.3M
Modulation of Choroid Plexus Immuno-secretory Function to Restore Cerebrospinal Fluid Homeostasis in HydrocephalusR01NS109358 · NINDS · YALE UNIVERSITY · PI Kristopher T. Kahle · 2018 to 2026
$2.4M
NINDS NIH HHS R01 NS109358NINDS NIH HHS R01 NS117609
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Identifiers

PMID40644723
PMCPMC12477702

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.