ArticleRheumatology (Oxford, England)2025
Risk of total and cause-specific mortality in patients with rheumatoid arthritis-associated interstitial lung disease or bronchiectasis.
Article in Rheumatology (Oxford, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Recent Knowledge Regarding the Epidemiology, Exacerbating Factors, and Treatment of Rheumatoid Arthritis Complicated by Interstitial Lung Disease.Journal of clinical medicine · 2026Review
- Incidence and disease burden of bronchiectasis in systemic lupus erythematosus: a nationwide population-based study in Korea.RMD open · 2026Article
- Evolving landscape of imaging-based evaluation in systemic autoimmune rheumatic disease-associated interstitial lung disease: from visual assessment to quantitative artificial intelligence-assisted evaluation.Journal of rheumatic diseases · 2026Review
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9 authors.
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Abstract
objectivesTo investigate total and cause-specific mortality risk among rheumatoid arthritis-associated lung disease (RA-LD) compared with RA patients without lung disease (RA-no LD).
methodsWe conducted a retrospective cohort study using the Mass General Brigham Biobank (Boston, MA), comparing RA-LD cases to RA-no LD comparators matched by calendar date, age, sex and RA duration. RA-LD was verified by medical record review and chest imaging for clinically apparent RA-associated interstitial lung disease (RA-ILD) and/or RA-associated bronchiectasis (RA-BR). Outcomes included total and cause-specific mortality (respiratory, cancer, cardiovascular, infection). Total mortality was analysed using Cox regression, and cause-specific mortality was analyzed using Fine and Gray models estimating subdistribution hazard ratios (sdHR) and 95% confidence intervals (CI), adjusted for propensity scores.
resultsWe analyzed 221 RA-LD cases (151 RA-ILD and 70 RA-BR) and 980 RA-no LD comparators. RA-LD patients had higher total mortality (34.0 vs 13.1 per 1000 person-years; HR 1.97, 95%CI 1.43-2.70). Infection-related mortality was more common in RA-LD patients (7% vs 3%, P = 0.002). RA-LD was associated with increased respiratory (13.1 vs 1.7 per 1000 person-years; sdHR 6.68, 95%CI 3.19-14.00) and lung infection-related mortality (6.3 vs 1.4 per 1000 person-years; sdHR 3.33, 95%CI 1.32-8.37), particularly in RA-ILD patients. RA-BR patients had higher cancer mortality (8.6 vs 2.3 per 1000 person-years; sdHR 2.89, 95%CI 1.11-7.47).
conclusionRA-LD, particularly RA-ILD, is associated with higher mortality, especially respiratory and infection-related mortality. RA-BR is associated with increased respiratory and cancer mortality. While larger studies are needed, these findings emphasize the need for improved treatments for RA-LD, effective infection prevention, and vigilant cancer surveillance.
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