ArticleScience advances2025
Constraining biorecalcitrance of carboxyl-rich alicyclic molecules in the ocean.
Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed.
- Article
- Global dispersal of macroalgae-derived recalcitrant DOC may substantially contribute to deep-ocean carbon storage.Science advances · 2026Article
- Chromatography Coupled to High-Resolution Mass Spectrometry Analysis Reveals Flaws in van Krevelen Compound Class Assignments in DOM.Environmental science & technology · 2026Article
- Graph-based understanding of isomeric diversity in complex dissolved organic matter.Communications chemistry · 2026Article
- Contrasting salinity regimes reshape microbe-DOM coupling and reduce recalcitrant dissolved organic carbon preservation in a salt lake.The ISME journal · 2026Article
- Temperature Thresholds Govern Microbial-Mediated Dissolved Organic Carbon Dynamics in Coastal Ecosystems.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Accumulation of recalcitrant dissolved organic carbon during cyanobacterial blooms in Meiliang Bay, Lake Taihu: insights into the microbial carbon pump.Frontiers in microbiology · 2026Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Marine dissolved organic matter (DOM) is one of Earth's largest long-term carbon reservoirs, critical to the global carbon cycle. A key breakthrough in understanding this pool is the identification of biorefractory carboxyl-rich alicyclic molecules (CRAM). Recent studies have challenged the biorecalcitrance of CRAM but lacked detailed molecular evidence. Using advanced online countergradient liquid chromatography-Fourier transform ion cyclotron resonance mass spectrometry to track microbial incubation, we revealed a wide spectrum of CRAM bioavailability regulated by molecular polarity. CRAM with lower polarity were preferentially degraded, whereas microbial reworking led to production of higher-polarity CRAM, characterized by increased oxidation state, nitrogen content, and aromaticity. Some microbially transformed CRAM were frequently detected in a global DOM dataset of 1485 seawater samples, suggesting their potential persistence in marine environments. This study provides molecular insights into the biorecalcitrance and transformation pathway of CRAM, underscoring the complexity and dynamic nature of marine organic carbon cycling.
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Registered trials
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