Evidence map›Paper›PMID 40644532›Full record

ArticleScience advances2025

Wearing bacteriophages individually with an adhesive drug-loadable nanohelmet for treating ocular infections.

Lu Meng, Fengmin Yang, Zhenping Cao, Chuhan Wang, Ju Chen, Yufeng Zhu, Kexin Wang, Jinyao Liu, Deyue Yan, Yan Pang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Polysaccharide-Based Encapsulation of Microbes for Enhanced Microbial Therapy.Polymer science & technology (Washington, D.C.) · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Lu MengSchool of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China.ORCID 0000-0003-3297-6377
Fengmin YangState Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute, Shanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine, Institute of Molecular Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China.ORCID 0000-0003-1057-6495
Zhenping CaoState Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute, Shanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine, Institute of Molecular Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China.ORCID 0000-0002-5190-9674
Chuhan WangState Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute, Shanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine, Institute of Molecular Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China.ORCID 0009-0008-0962-0341
Ju ChenState Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute, Shanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine, Institute of Molecular Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China.
Yufeng ZhuState Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute, Shanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine, Institute of Molecular Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China.
Kexin WangState Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute, Shanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine, Institute of Molecular Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China.
Jinyao LiuState Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute, Shanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine, Institute of Molecular Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China.ORCID 0000-0002-6044-2033
Deyue YanSchool of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China.ORCID 0000-0003-0969-227X
Yan PangSchool of Pharmaceutical Sciences, Shanghai Jiao Tong University, Shanghai 200240, China.ORCID 0000-0002-6722-9403

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ocular infections pose notable blindness risks. Despite its advantages in inhibiting multidrug-resistant bacteria and eliminating biofilms, phage therapy suffers low phage vitality, limited ocular retention, and lack of anti-inflammatory abilities toward ocular infections. Here, wearing phages individually with an adhesive drug-loadable nanohelmet is reported to advance phage therapy. The nanohelmet is formed by depositing arginine-glycine-aspartic acid-modified chitosan on negatively charged phage head through electrostatic interactions, followed by codepositing anti-inflammatory agents via physical adsorption. Nanohelmet formation shows a negligible influence on phage vitality and is applicable to helmet diverse phages. Because of the cationic nature and the presence of arginine-glycine-aspartic acid sequence, such nanohelmet exhibits a double-lock adhesion fashion to ocular surface, prolonging phage retention after instillation. Together with sustained drug release, helmeted phages potently inhibit bacteria, eliminate biofilms, and effectively suppress localized inflammation. In mice with multidrug-resistant pathogen-induced keratitis, helmeted phages achieve superior therapeutic efficacies, even compared to clinical therapeutics.

Indexed as

AdhesivesBacteriophagesEye InfectionsKeratitisPhage TherapyAnimalsAnti-Bacterial AgentsBiofilmsHumansMiceAdhesivesAnti-Bacterial Agents

Identifiers

PMID40644532
PMCPMC12248281

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.