ArticlePlant biotechnology journal2025
Transcription factors ERF74/77/108/125 enhance thermotolerance in rice by regulating common and distinct heat-responsive gene expression.
Article in Plant biotechnology journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- The transcriptional cascade CiERF023Horticulture research · 2026Article
- Temperature regulation in plants: From molecular mechanisms to climate-resilient crop improvement.Journal of integrative plant biology · 2026Review
- OsPUP1 Modulates Cytokinin Distribution and Antioxidant Defense to Regulate Heat Stress Tolerance in Rice.Antioxidants (Basel, Switzerland) · 2026Article
- Transcriptional reprogramming of heat-sensitive maize anther development under heat stress.BMC plant biology · 2026Article
- Transcriptome-based investigation of the response and repair mechanisms in the photosynthetic system of Cycas panzhihuaensis under dual high-temperature and drought stress.BMC plant biology · 2026Article
- Integrated Transcriptomic and Metabolomic Analyses Provide Insights into the Response of Red Clover (International journal of molecular sciences · 2026Article
- Combined transcriptomics and metabolomics analysis reveals the molecular responses of heat tolerance during germination stage in sesame.Frontiers in plant science · 2026Article
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8 authors.
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Abstract
Heat stress severely impacts crop productivity, necessitating the identification of key regulatory genes for improving thermotolerance. Here, we demonstrate that the rice nuclear-localized AP2/ERF transcription factors ERF74/77/108/125 function as critical regulators of heat stress responses. Loss-of-function mutant seedlings of ERF74/77 or ERF108/125 exhibit increased heat sensitivity, whereas overexpression of each ERF74, ERF77, ERF108 or ERF125 individually enhances thermotolerance, indicating their positive role in heat adaptation. These ERFs activate heat-responsive genes, with ERF74/77 and ERF108/125 sharing common targets while maintaining distinct regulatory networks. Mechanistically, ERF74/77/108/125 directly bind to the promoter of HsfA2c, a central heat shock transcription factor, and activate its expression. Genetic evidence confirms that HsfA2c is essential for mediating thermotolerance in rice. Our findings reveal a hierarchical regulatory module where ERF74/77/108/125 orchestrate heat stress responses by activating distinct and common downstream genes including HsfA2c, providing potential targets for engineering climate-resilient rice.
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