Evidence map›Paper›PMID 40644511›Full record

ArticleScience immunology2025

Multimodal delineation of a layer of effector function among exhausted CD8 T cells in tumors.

Arja Ray, Molly Bassette, Kenneth H Hu, Lomax F Pass, Tristan Courau, Bushra Samad, Alexis J Combes, Vrinda Johri, Brittany Davidson, Katherine Wai and 4 more

Abstract read
In one paragraph

Article in Science immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. All-trans retinoic acid suppresses CD8Signal transduction and targeted therapy · 2026
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Arja RayDepartment of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA.ORCID 0000-0003-2305-2324
Molly BassetteDepartment of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA.ORCID 0000-0001-8658-8148
Kenneth H HuDepartment of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA.ORCID 0000-0002-0294-0202
Lomax F PassDepartment of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA.
Tristan CourauDepartment of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA.ORCID 0000-0003-1819-9516
Bushra SamadImmunoX Initiative, University of California, San Francisco, San Francisco, CA 94143, USA.ORCID 0000-0002-2893-0897
Alexis J CombesDepartment of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA.ORCID 0000-0002-9110-6542
Vrinda JohriImmunoX Initiative, University of California, San Francisco, San Francisco, CA 94143, USA.ORCID 0000-0001-7341-4675
Brittany DavidsonImmunoX Initiative, University of California, San Francisco, San Francisco, CA 94143, USA.ORCID 0000-0003-3538-2822
Katherine WaiDepartment of Otolaryngology Head and Neck Surgery, University of California, San Francisco, San Francisco, CA 94143, USA.
Patrick HaDepartment of Otolaryngology Head and Neck Surgery, University of California, San Francisco, San Francisco, CA 94143, USA.ORCID 0000-0003-0306-6147
Grace HernandezDepartment of Anatomy, University of California, San Francisco, San Francisco, CA 94143, USA.ORCID 0000-0001-6494-6194
Itzia Zaleta-LinaresDepartment of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA.
Matthew F KrummelDepartment of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA.ORCID 0000-0001-7915-3533

Funding

The Tumor Microenvironment Niche of Type I conventional Dendritic CellsR01CA197363 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MATTHEW F KRUMMEL · 2017 to 2026
$4.5M
CONTROL OF T CELL SYNAPSE STABILIZATION AND SIGNALINGR37AI052116 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MATTHEW F KRUMMEL · 2023 to 2026
$2.5M
NCI NIH HHS R01 CA197363NIAID NIH HHS R37 AI052116
6 · The paper itself

Abstract

Undescribed functional axes may intersect with the trajectory of T cell exhaustion (T

Indexed as

CD8-Positive T-LymphocytesHead and Neck NeoplasmsAnimalsAntigens, CDAntigens, Differentiation, T-LymphocyteCD69 AntigensCell Line, TumorFemaleHumansLectins, C-TypeLymphocyte ActivationMiceAntigens, CDAntigens, Differentiation, T-LymphocyteCD69 AntigensLectins, C-Type

Identifiers

PMID40644511
PMCPMC12404540

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.