Evidence map›Paper›PMID 40644462›Full record

ArticlePLOS digital health2025

Raising awareness of potential biases in medical machine learning: Experience from a Datathon.

Harry Hochheiser, Jesse Klug, Thomas Mathie, Tom J Pollard, Jesse D Raffa, Stephanie L Ballard, Evamarie A Conrad, Smitha Edakalavan, Allan Joseph, Nader Alnomasy and 13 more

Erratum issuedAbstract read
In one paragraph

Article in PLOS digital health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

23 authors.

Harry HochheiserDepartment of Biomedical Informatics, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.ORCID https://orcid.org/0000-0001-8793-9982
Jesse KlugUPMC Intensive Care Unit Service Center, UPMC, Pittsburgh, Pennsylvania, United States of America.
Thomas MathieDepartment of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.
Tom J PollardMIT Laboratory for Computational Physiology, Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America.ORCID https://orcid.org/0000-0002-5676-7898
Jesse D RaffaMIT Laboratory for Computational Physiology, Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America.ORCID https://orcid.org/0000-0001-8665-2429
Stephanie L BallardHealth Informatics, School of Health and Rehabilitation Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.ORCID https://orcid.org/0000-0002-6648-4488
Evamarie A ConradHealth Informatics, School of Health and Rehabilitation Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.
Smitha EdakalavanDepartment of Biomedical Informatics, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.ORCID https://orcid.org/0000-0002-2107-9489
Allan JosephDivision of Critical Care Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States of America.ORCID https://orcid.org/0000-0003-2768-0889
Nader AlnomasyHealth Informatics, School of Health and Rehabilitation Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.ORCID https://orcid.org/0000-0002-4865-1190
Sarah NutmanDepartment of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.
Veronika HillHealth Informatics, School of Health and Rehabilitation Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.
Sumit KapoorDepartment of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.
Eddie Pérez ClaudioDepartment of Biomedical Informatics, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.ORCID https://orcid.org/0000-0002-8452-3778
Olga V KravchenkoDepartment of Family and Community Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.
Ruoting LiDepartment of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.ORCID https://orcid.org/0000-0002-9138-4606
Mehdi NourelahiDepartment of Biomedical Informatics, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.ORCID https://orcid.org/0000-0002-6986-3184
Jenny DiazHealth Informatics, School of Health and Rehabilitation Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.
W Michael TaylorDepartment of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.ORCID https://orcid.org/0009-0001-0387-194X
Sydney R RooneyDivision of Cardiology, Department of Pediatrics, Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.ORCID https://orcid.org/0000-0003-3382-2492
Maeve WoeltjeDepartment of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.
Leo Anthony CeliMIT Laboratory for Computational Physiology, Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America.ORCID https://orcid.org/0000-0001-6712-6626
Christopher M HorvatDepartment of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.ORCID https://orcid.org/0000-0002-1593-2252

Funding

Bridge2AI: Patient-Focused Collaborative Hospital Repository Uniting Standards (CHoRUS) for Equitable AIOT2OD032701 · OD · MASSACHUSETTS GENERAL HOSPITAL · PI BIHORAC, AZRA, CLERMONT, GILLES · 2022 to 2025
$24.6M
MUST Data Science Research Hub (MUDSReH) - Democratized Trusted Research Environment (dTRE)U54TW012043 · FIC · MBARARA UNIVERSITY/SCIENCE/ TECHNOLOGY · PI Leo Anthony G Celi, Jessica Elizabeth Haberer · 2021 to 2026
$6.9M
Critical Care Informatics: Ethical considerations around the use and sharing of health-related dataR01EB017205 · NIBIB · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI CELI, LEO ANTHONY G, MARK, ROGER GREENWOOD · 2014 to 2021
$3.8M
FIC NIH HHS U54 TW012043NIBIB NIH HHS R01 EB017205NIH HHS OT2 OD032701
6 · The paper itself

Abstract

objectiveTo challenge clinicians and informaticians to learn about potential sources of bias in medical machine learning models through investigation of data and predictions from an open-source severity of illness score.

methodsOver a two-day period (total elapsed time approximately 28 hours), we conducted a datathon that challenged interdisciplinary teams to investigate potential sources of bias in the Global Open Source Severity of Illness Score. Teams were invited to develop hypotheses, to use tools of their choosing to identify potential sources of bias, and to provide a final report.

resultsFive teams participated, three of which included both informaticians and clinicians. Most (4/5) used Python for analyses, the remaining team used R. Common analysis themes included relationship of the GOSSIS-1 prediction score with demographics and care related variables; relationships between demographics and outcomes; calibration and factors related to the context of care; and the impact of missingness. Representativeness of the population, differences in calibration and model performance among groups, and differences in performance across hospital settings were identified as possible sources of bias. DISCUSSION: Datathons are a promising approach for challenging developers and users to explore questions relating to unrecognized biases in medical machine learning algorithms.

Identifiers

PMID40644462
PMCPMC12250157

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.