ReviewAnnals of medicine2025
Research progress on nanotoxicity and detoxification of cobalt in metal-based implants.
Review in Annals of medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Emerging regenerative strategies for spinal cord injury: exosome-derived mechanisms and therapeutic insights.Frontiers in neuroscience · 2025Pooled it
- Tailoring Cobalt-Based Nanomaterials through Doping and Vacancy Engineering for Advanced Hydrogen Evolution Reaction (HER) and Oxygen Evolution Reaction (OER) Electrolysis.Small (Weinheim an der Bergstrasse, Germany) · 2026Review
- Associations of metals and micronutrients with functional disability in Chinese older adults: a mixture analysis approach.Scientific reports · 2026Article
- Beyond Biocompatibility: Immune Dysregulation, Oxidative Stress, and Tissue Intolerance Associated with Ti-6Al-4V Dental Implants-A Critical Review and Perspective.Antioxidants (Basel, Switzerland) · 2026Review
- Magneto-X Effects in Magnetic Soft Materials and Their Applications.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Morphological and Cytotoxic Effects of Metal Salts on Osteoblast Cells in Three-Dimensional Spheroidal Cultures.Journal of toxicology · 2026Article
- Research progress on ferroptosis in drug resistance and therapy of gastric cancer.Journal of cancer research and clinical oncology · 2025Review
- Influence of radial clearance on Tresca stress in AlScientific reports · 2025Article
- New Approaches and Strategies for the Repurposing of Iron Chelating/Antioxidant Drugs for Diseases of Free Radical Pathology in Medicine.Antioxidants (Basel, Switzerland) · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCobalt nanoparticles (CoNPs), a primary wear debris from joint prostheses, exhibit significant cytotoxicity. This review aims to synthesize current understanding of CoNPs' toxicity mechanisms, their local and systemic pathological effects, the emerging role in ferroptosis, potential detoxification strategies, and outline critical future research directions. DISCUSSION: CoNPs are internalized by cells, primarily
conclusionsCoNPs released from joint prostheses present substantial local and systemic health hazards. Their toxicity is primarily mediated through lysosomal degradation, ROS overproduction, and the induction of cell death, including ferroptosis. While mechanisms are increasingly understood, further research is crucial to fully elucidate the long-term systemic consequences and to develop effective clinical detoxification and preventative strategies for patients with cobalt-containing implants.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.