ReviewThe Analyst2025
MALDI mass spectrometry imaging of extracellular matrix proteins.
Review in The Analyst, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- Enzyme-mediated remodeling of the extracellular matrix and glycocalyx to enhance immunotherapy in solid tumors.Bioengineering & translational medicine · 2026Review
- Nascent extracellular matrix: the missing piece in hydrogel design.Cell biomaterials · 2026Article
- Artificial Intelligence Virtual Organoids (AIVOs).Bioactive materials · 2026Review
- Rapid and efficient in situ digestion of proteins by SoniCoat for MALDI mass spectrometry imaging.Analytical and bioanalytical chemistry · 2026Article
- Comparative proteomic analysis of the ECM composition of the human omentum and mesentery, the main sites of ovarian cancer metastasis.iScience · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
The identity, quantity, and spatial distribution of extracellular matrix (ECM) proteins in tissues defines the function of cells within. Dysregulation of ECM proteins can be coincident with or even drive various pathological conditions. Common techniques that are used to spatially detect and identify ECM proteins include magnetic resonance imaging (MRI), immunohistochemistry (IHC), second harmonic generation (SHG) imaging, and scanning electron microscopy (SEM). However, these techniques typically limit detection to only a few proteins simultaneously. Matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) has emerged as a tool capable of detecting various biomolecules such as lipids, proteins, peptides, and glycans in a spatially-defined manner due to its high molecular specificity. However, it is rarely applied to ECM proteins because of their highly cross-linked nature, relatively low abundance, and prevalence of post-translational modifications. This perspective discusses the current state and future of MALDI-MSI of ECM proteins, details the technical hurdles limiting the adoption of MALDI-MSI for ECM imaging, and summarizes the potential opportunities that MALDI-MSI has for spatially resolving ECM proteins in healthy and diseased tissues.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.