Evidence map›Paper›PMID 40643866›Full record

SynthesisProbiotics and antimicrobial proteins2026

Clinical Evidence on the Health Benefits and Safety of Probiotic Lacticaseibacillus rhamnosus: A Systematic Review.

Yu Yang, Jing Sui, Wang Liao, Shaokang Wang, Da Pan, Guiju Sun, Peng Gao, Xuesong Xiang, Hui Xia

Abstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Probiotics and antimicrobial proteins, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Trial
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Ultrasound-assisted fermentation of buttermilk byCurrent research in food science · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yu Yang *Key Laboratory of Environmental Medicine and Engineering of Ministry of Education, Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing, 210009, China.
Jing Sui *Key Laboratory of Environmental Medicine and Engineering of Ministry of Education, Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing, 210009, China.
Wang LiaoKey Laboratory of Environmental Medicine and Engineering of Ministry of Education, Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing, 210009, China.
Shaokang WangKey Laboratory of Environmental Medicine and Engineering of Ministry of Education, Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing, 210009, China.
Da PanKey Laboratory of Environmental Medicine and Engineering of Ministry of Education, Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing, 210009, China.
Guiju SunKey Laboratory of Environmental Medicine and Engineering of Ministry of Education, Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing, 210009, China.
Peng GaoDanone Institute China, Beijing, China.
Xuesong XiangChinese Center for Disease Control and Prevention, National Institute of Nutrition and Health, Beijing, China. xiangxs@ninh.chinacdc.cn.
Hui XiaKey Laboratory of Environmental Medicine and Engineering of Ministry of Education, Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing, 210009, China. huixia@seu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In recent years, the health benefits of probiotics have received increasing attention. As one of the most common probiotics, the health efficacy and safety of Lacticaseibacillus rhamnosus (L. rhamnosus) have become the research focus. For this reason, the review aimed to comprehensively evaluate the impact of L. rhamnosus on human health and various diseases. PubMed, Embase, Cochrane Library, and Web of Science databases were searched for randomized controlled trials (RCTs) investigating the effect of L. rhamnosus and multiple diseases. A digital search was conducted following systematic review guidelines, and 51 studies met inclusion criteria from a total of 1595 articles. The results of this review indicate that L. rhamnosus provides potential health benefits in various diseases. For example, studies have shown that it may alleviate clinical symptoms of atopic dermatitis in children, modulate gut microbiota to improve symptoms in patients with irritable bowel syndrome (IBS), and potentially reduce the incidence of gestational diabetes mellitus. L. rhamnosus is generally considered safe for healthy individuals, with no serious adverse events commonly reported in the general population. However, occasional adverse effects have been documented in special populations such as critically ill patients, pregnant women, and infants, and caution is advised when used in these groups. Future studies investigating the health benefits of L. rhamnosus still need to design more comprehensive RCTs and expand the sample size to better study the impact of L. rhamnosus on various diseases.

Indexed as

Lacticaseibacillus rhamnosusProbioticsFemaleGastrointestinal MicrobiomeHumansPregnancyRandomized Controlled Trials as TopicHealth benefitsLacticaseibacillus rhamnosusProbioticsSafety assessment

Identifiers

PMID40643866

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.