Evidence map›Paper›PMID 40643829›Full record

ArticleAIDS and behavior2025

Barriers and Facilitators to PrEP Adherence among Transgender and Non-binary Individuals: A Mixed-Methods Analysis of Psychosocial Factors and Health Belief Model Constructs.

D Paltin, M Prescott, J Ma, S Yeager, L Ham, S Serrano, J Narez, J Delgado, L Burke, B Gouaux and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in AIDS and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

D PaltinSan Diego State University, University of California San Diego Joint Doctoral Program in Clinical Psychology, San Diego, CA, USA.ORCID http://orcid.org/0000-0001-7632-4464
M PrescottSan Diego State University, University of California San Diego Joint Doctoral Program in Clinical Psychology, San Diego, CA, USA.
J MaSan Diego State University, University of California San Diego Joint Doctoral Program in Clinical Psychology, San Diego, CA, USA.
S YeagerUniversity of California, San Diego, CA, USA.
L HamSan Diego State University, University of California San Diego Joint Doctoral Program in Clinical Psychology, San Diego, CA, USA.
S SerranoSan Diego State University, University of California San Diego Joint Doctoral Program in Clinical Psychology, San Diego, CA, USA.
J NarezUniversity of California, San Diego, CA, USA.
J DelgadoUniversity of California, San Diego, CA, USA.
L BurkeUniversity of California, San Diego, CA, USA.
B GouauxUniversity of California, San Diego, CA, USA.
M BeckwithUniversity of California, San Diego, CA, USA.
S R MorrisUniversity of California, San Diego, CA, USA.
D J MooreUniversity of California, San Diego, CA, USA.
J L MontoyaUniversity of California, San Diego, CA, USA. jlmontoya@health.ucsd.edu.

Funding

VirologyP30AI036214 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SONIA JAIN · 1994 to 2026
$78.4M
STRUCTURAL NEUROIMAGING COREP30MH062512 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Jennifer E Iudicello · 2001 to 2026
$50.4M
Training in Research on Addictions in Interdisciplinary NeuroAIDS (TRAIN)T32DA031098 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Jennifer E Iudicello, DAVID J MOORE · 2011 to 2026
$4.6M
An integrated incentive-based treatment to optimize HIV treatment engagement among persons who use methamphetamineK23DA051324 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MONTOYA, JESSICA LYNETTE · 2021 to 2025
$1.0M
Developing a Risk Index for Functional Decline in Middle-Aged and Older Adults with HIVF31AG084417 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI HAM, LILLIAN · 2023 to 2024
$82k
California HIV/AIDS Research Program H22BD4432SCalifornia HIV/AIDS Research Program PR15-SD-021NIAID NIH HHS P30 AI036214NIA NIH HHS F31 AG084417NIA NIH HHS F31AG084417NIDA NIH HHS 5T32DA031098NIDA NIH HHS K23 DA051324NIDA NIH HHS K23DA051324NIDA NIH HHS L30 DA056940NIDA NIH HHS T32 DA031098NIMH NIH HHS P30 MH062512
6 · The paper itself

Abstract

Despite known benefits of Motivational Interviewing (MI) for medication adherence, its effectiveness in supporting pre-exposure prophylaxis (PrEP) adherence among transgender and nonbinary (TGNB) populations remains underexplored. This study applies mixed-methods analysis to understand PrEP adherence among TGNB individuals who received a daily individualized text-message intervention and phone-based MI for non-adherence to PrEP. Individuals who did not respond to three consecutive messages were identified as potential MI recipients. We had three objectives: (1) examine psychosocial differences between participants who needed MI (MI Indicated group; n = 81) versus those who did not (MI Not Indicated group; n = 48), (2) assess whether Health Belief Model (HBM) constructs were associated with PrEP adherence, and (3) identify adherence barriers and facilitators. This secondary analysis builds on primary intervention outcomes published in Morris et al. (J Acquire Immune Defic Syndr 91:453-459, 2022). We conducted multivariable linear regression on psychosocial measures and PrEP adherence, and inductive qualitative analysis on a subset of participants who completed at least one MI session (n = 60). Results were deductively mapped onto HBM constructs. Significant differences emerged between MI groups in HBM constructs, with the MI Indicated group reporting higher perceived HIV risk, stress, depressive symptoms, and poorer coping and self-efficacy. Findings highlight the need for personalized interventions to support PrEP adherence, mental health, and HIV risk perception among TGNB individuals. Future adherence interventions may benefit from assessing and addressing HBM constructs. To support the Ending the HIV Epidemic initiative, it is critical to enhance access to facilitators and mitigate barriers to PrEP adherence for this population.

Indexed as

Anti-HIV AgentsHealth Belief ModelHIV InfectionsMedication AdherencePre-Exposure ProphylaxisSexual and Gender MinoritiesTransgender PersonsAdultFemaleHumansMaleMiddle AgedMotivational InterviewingText MessagingYoung AdultAnti-HIV AgentsHIV preventionMotivational interviewingNonbinaryPrEP adherenceTransgender

Identifiers

PMID40643829
PMCPMC12500775

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.