ArticleTissue engineering and regenerative medicine2025
SIRT4 Regulated by a Mechanosensor, PIEZO1 Shows a Protective Function to Suppress Ox-LDL Uptake in Endothelial Cells.
Article in Tissue engineering and regenerative medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundEndothelial cells (ECs) are key regulators of vascular function, adapting to mechanical forces, such as shear stress to maintain vascular homeostasis. Disruption of this adaptation, particularly in the regions of disturbed flow, contributes to endothelial dysfunction and the development of atherosclerosis later on.
methodsWe prepared a custom-designed PDMS-based flow chamber to apply controlled shear stress (2 or 7 dynes/cm
resultsWe demonstrated that the mechanosensitive ion channel PIEZO1, regulates SIRT4 expression in response to shear stress. Under atheroprotective shear stress (7 dyne/cm
conclusionCurrent findings suggest that the PIEZO1-SIRT4 axis may modulate endothelial responses to shear stress, offering a protective mechanism against Ox-LDL-induced dysfunction and pathology. Our study underscores the potential of SIRT4 as a therapeutic target to mitigate vascular disorders associated with oxidative stress and disturbed blood flow.
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