Two duodenal sessile serrated lesions in a patient with serrated polyposis syndrome: case report and review of the literature.

Hitomi Hori, Yasuaki Kitamura, Saori Matsui, Kyosuke Takahashi, Mayumi Inaba, Akihiko Watanabe

Abstract readCase ReportsReview

In one paragraph

Review in Clinical journal of gastroenterology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Incidental Diagnosis of Serrated Polyposis Syndrome of the Small and Large Bowel Treated Endoscopically and Surgically: A Case Report.Cureus · 2026
Article

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Hitomi HoriDepartment of Gastroenterology and Hepatology, Yodogawa Christian Hospital, 1-7-50 Kunijima, Higashiyodogawa-ku, Osaka, 533-0024, Japan.

Yasuaki KitamuraDepartment of Gastroenterology and Hepatology, Yodogawa Christian Hospital, 1-7-50 Kunijima, Higashiyodogawa-ku, Osaka, 533-0024, Japan. 3116041@ych.or.jp.

Saori MatsuiDepartment of Gastroenterology and Hepatology, Yodogawa Christian Hospital, 1-7-50 Kunijima, Higashiyodogawa-ku, Osaka, 533-0024, Japan.

Kyosuke TakahashiDepartment of Gastroenterology and Hepatology, Yodogawa Christian Hospital, 1-7-50 Kunijima, Higashiyodogawa-ku, Osaka, 533-0024, Japan.

Mayumi InabaDepartment of Pathology, Yodogawa Christian Hospital, Osaka, Japan.

Akihiko WatanabeDepartment of Gastroenterology and Hepatology, Yodogawa Christian Hospital, 1-7-50 Kunijima, Higashiyodogawa-ku, Osaka, 533-0024, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The serrated neoplastic pathway has been reported to be involved in the development of colorectal cancer, and serrated lesions are recognized to have malignant potential. Recently, serrated lesions of the duodenum have been increasingly reported. Serrated polyposis syndrome (SPS) is characterized by multiple serrated lesions in the colon; however, it is unknown whether serrated lesions in the duodenum occur in patients with SPS. A 58-year-old man with SPS underwent a routine colonoscopy. When he underwent esophagogastroduodenoscopy for screening, two 4-mm white flat-elevated lesions in the second portion of the duodenum were found. The biopsy results were suggestive of sessile serrated lesions (SSLs); therefore, we performed endoscopic mucosal resection with a cap-fitted pan-endoscope for therapeutic purposes. Pathology results showed an SSL in the duodenum. One SSL lesion was positive for the BRAF mutation; multiple duodenal SSLs in patients with SPS are rare, and there are no previous reports of BRAF mutation-positive SSLs. The grade and molecular abnormalities of duodenal SSLs are currently unknown, as is the relationship between SPS and duodenal SSL. Further case accumulation is expected.

Indexed as

Adenomatous Polyposis ColiDuodenal NeoplasmsIntestinal PolyposisEndoscopic Mucosal ResectionHumansMaleMiddle AgedProto-Oncogene Proteins B-rafBRAF protein, humanProto-Oncogene Proteins B-rafBRAF mutationDuodenumSerrated pathwaySerrated polyposis syndromeSessile serrated lesion

Identifiers

PMID40643790

DOI10.1007/s12328-025-02165-4

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.