Evidence map›Paper›PMID 40643762›Full record

ReviewBioresources and bioprocessing2025

Biosynthesis of conjugated linoleic acid: current status and future perspectives.

Lu Lin, Mei-Li Sun, Kaifeng Wang, Jian Gao, Xiao-Jun Ji, Quanyu Zhao

Abstract readReview
In one paragraph

Review in Bioresources and bioprocessing, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Lu LinState Key Laboratory of Materials-Oriented Chemical Engineering, College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, 211816, People's Republic of China.
Mei-Li SunState Key Laboratory of Materials-Oriented Chemical Engineering, College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, 211816, People's Republic of China.
Kaifeng WangState Key Laboratory of Materials-Oriented Chemical Engineering, College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, 211816, People's Republic of China.
Jian GaoSchool of Marine and Bioengineering, Yancheng Institute of Technology, Yancheng, 224051, People's Republic of China.
Xiao-Jun JiState Key Laboratory of Materials-Oriented Chemical Engineering, College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, 211816, People's Republic of China. xiaojunji@njtech.edu.cn.ORCID http://orcid.org/0000-0002-6450-0229
Quanyu ZhaoSchool of Pharmaceutical Sciences, Nanjing Tech University, Nanjing, 211816, People's Republic of China. zhaoqy@njtech.edu.cn.

Funding

National Natural Science Foundation of China 22178173
6 · The paper itself

Abstract

Conjugated linoleic acid (CLA) has received much attention for its beneficial physiological effects, particularly anticancer and metabolic control activity. However, traditional sources rely on extraction and chemical synthesis, both of which are not commercially viable. This article describes the research progress on sustainable alternative biosynthesis methods for the production of CLA, which is an attractive approach for commercial production because of its high stereoselectivity and convenient purification process. Here, we offer a comprehensive review of the current state and research progress in the biosynthesis of CLA, including production strains, biosynthesis mechanisms and improvements in the biosynthesis of CLA by genetic engineering. Finally, future research directions for improving the biosynthesis of CLA are defined in the light of recent advances, barriers and trends in this field.

Indexed as

BiotransformationConjugated Linoleic acidDe Novo biosynthesisLinoleic acid isomeraseSynthetic biology

Identifiers

PMID40643762
PMCPMC12254105

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.