Trial reportClinical oral investigations2025
Effect of 0.8% Hyaluronic Acid-Based Gel on Clinical and Biomolecular parameters in the surgical periodontal treatment of Stage III periodontitis patients: a randomized, split-mouth clinical trial.
Trial report in Clinical oral investigations, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Effects of Hyaluronic Acid in the Surgical Treatment of Periodontitis: A Systematic Review.Oral health & preventive dentistry · 2026Pooled it
- Clinical efficacy of different biomaterials for the regenerative treatment of periodontal intrabony defects: a systematic review and Bayesian network meta-analysis.BMC oral health · 2026Pooled it
- The Emerging Role of Hyaluronic Acid as a Multifunctional Regenerative Agent in Periodontal Healing.Gels (Basel, Switzerland) · 2026Review
- Hydrogel-Based Therapeutic Strategies for Periodontal Tissue Regeneration: Advances, Challenges, and Future Perspectives.Pharmaceutics · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
objectivesThis study aimed to assess the effect of the application of 0.8% hyaluronic acid (HA) gel together with open flap debridement (OFD) on clinical parameters and inflammatory and oxidative biomarkers in gingival crevicular fluid (GCF) of the patients with stage III periodontitis. MATERIALS AND
methodsThis split-mouth study included 18 patients diagnosed with Stage III Grade B or C periodontitis. Quadrants were randomly assigned to test (OFD + 0.8% HA gel) and control groups (OFD alone). Clinical parameters and GCF samples were obtained at the treated sites at baseline (T0), at pre-surgery (T1), 1 month (T2) and 6 months (T3) post-surgery. Interleukin (IL)-6, IL-8, IL-10, IL-17 A, total antioxidant status (TAS), and total oxidant status (TOS) levels in GCF were analyzed using enzyme-linked immunosorbent assay.
resultsThe lower GCF IL-6, IL-8, IL-17 A and TOS levels and higher GCF IL-10 and TAS levels were found after treatment (T1,T2,T3) compared to the T0 period in intragroup comparisons (P < 0.05). There were statistically significantly higher GCF IL-10 levels in the T2 and T3 periods and significantly lower GCF IL-17 A levels in the T3 period in the test group compared to the control group (P < 0.05), no significant difference was determined between the groups in GCF IL-6, IL-8, TAS and TOS levels during the time periods.
conclusionThe local application of 0.8% HA gel with OFD provides to beneficial effect GCF IL-10 and IL-17 A levels in severe periodontitis patients. CLINICAL RELEVANCE: The application of 0.8% HA gel addictive with OFD provides positive results in GCF IL-10 and IL-17 A levels in patients with Stage III periodontitis compared to OFD alone.
Indexed as
Identifiers
40643719What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.