ArticleAnnals of surgical oncology2025
Impact of Preoperative Diabetes on Insulin Management and Nutritional Status After Total or Completion Pancreatectomy.
Article in Annals of surgical oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundInsulin requirements after total or completion pancreatectomy (TP/CP) remain uncertain, complicating postoperative diabetes and nutritional care. This study uncovers key factors influencing these requirements.
methodsThis retrospective study included 53 patients who underwent TP/CP between July 2005 and October 2023. Data on the perioperative clinical, diabetic, and nutritional factors were also collected. Multivariable analyses were performed for the insulin-to-glucose ratio (IGR) on postoperative days (POD) 1 and 2 and the insulin dose during long-term follow-up.
resultsThe median insulin dose and IGR on POD 1 and 2 were 47 units/day and 0.26 units/g, respectively. The median insulin dose at discharge was 18 U/day, which increased to 23 U/day during follow-up. High preoperative HbA1c levels (odds ratio [OR], 8.68) and long operation time (OR 7.26) were determinants of high IGR. Although long-standing diabetes mellitus before surgery did not correlate with IGR, it was the sole predictor of high insulin requirement (OR 8.09) during follow-up (30 vs. 20 units/day). This resulted in improved nutritional status, as reflected by changes in body weight (P < 0.001) and nutritional scores (CONUT score, P = 0.041; geriatric nutritional risk index, P = 0.002). In contrast, patients without preoperative diabetes tended to require low insulin doses during follow-up, leading to poor diabetic control and worsening of nutritional status, as reflected in the CONUT score (P = 0.013).
conclusionsAdjusting insulin doses and controlling diabetes can be more challenging when performing TP/CP in patients without diabetes than in patients with long-standing diabetes mellitus. Careful management is required for these patients to achieve better nutritional status.
Indexed as
Identifiers
40643710What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.