People with down syndrome exhibit a blunted hemodynamic response to isometric handgrip but not cycling exercise.

João L Marôco, Tracy Baynard, Bo Fernhall

Abstract read

In one paragraph

Article in European journal of applied physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

João L MarôcoIntegrative Human Physiology Laboratory, Manning College of Nursing & Health Sciences, University of Massachusetts Boston, Boston, MA, USA. joao.maroco001@umb.edu.ORCID http://orcid.org/0000-0002-5691-5272

Tracy BaynardIntegrative Human Physiology Laboratory, Manning College of Nursing & Health Sciences, University of Massachusetts Boston, Boston, MA, USA.

Bo FernhallIntegrative Human Physiology Laboratory, Manning College of Nursing & Health Sciences, University of Massachusetts Boston, Boston, MA, USA.

Funding

American Heart Association 005028N

6 · The paper itself

Abstract

People with Down syndrome (DS) have a depressed heart rate (HR) and blood pressure (BP) response to exercise. We tested the hypothesis that people with DS, compared to controls (CON), would have more blunted HR and BP responses to isometric rather than dynamic cycling exercise. Twenty-eight individuals with DS and 14 controls (16-40 years) completed a 6-min cycling exercise at 50% body weight and 2-min handgrip isometric exercise at 30% maximum voluntary contraction (MVC). HR and BP were sampled via a single-lead system and finger photoplethysmography, respectively. Hemodynamic responses to both exercises were tested with linear mixed models. Individuals with DS showed a blunted HR increase to handgrip (DS: difference (d)

Indexed as

Down SyndromeExerciseHand StrengthHemodynamicsIsometric ContractionAdolescentAdultBicyclingBlood PressureFemaleHeart RateHumansMaleYoung AdultBlood pressureDown syndromeDynamic exerciseHeart rateIsometric exercise

Identifiers

PMID40643703

DOI10.1007/s00421-025-05901-3

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.