ArticleJournal of anesthesia2026
Comparison of cerebral oxygen saturation values determined by time-resolved spectroscopy and spatially resolved spectroscopy in pediatric patients with congenital heart disease.
Article in Journal of anesthesia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- "hDOS": an automated hybrid diffuse optical device for real-time noninvasive tissue monitoring: precision andJournal of biomedical optics · 2025Article
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5 authors.
Funding
Abstract
purposeTime-resolved spectroscopy (TRS) has recently become clinically available and offers superior measurement accuracy over conventional spatially resolved spectroscopy (SRS). This study evaluated the feasibility of transitioning from the SRS-based INVOS 5100C to the TRS-based tNIRS-1 by comparing cerebral oxygen saturation measurements taken during pediatric cardiac surgery.
methodsWe retrospectively analyzed data from 149 children (< 6 years) who had undergone cardiac surgery. We compared simultaneously measured cerebral tissue oxygen saturation (StO₂) (tNIRS-1) and regional cerebral oxygen saturation (rSO₂) (INVOS 5100C) after anesthesia induction. Both values were assessed against reference cerebral oxygen saturation (REF CX). Clinical decisions based on StO₂ and rSO₂ were also compared to current reference thresholds.
resultsThe Wilcoxon matched-pairs signed-rank test showed significantly lower StO₂ than rSO₂ (54.8 [48.9-61.0] vs. 69 [61-75], p < 0.0001); this observation was consistent across all age groups and cyanotic statuses. Bland-Altman analysis confirmed non-interchangeability (mean bias: - 13.1; limits: - 31.7 to 5.5). Compared with REF CX, rSO₂ more closely reflected true cerebral oxygenation (mean bias: - 5.7; limits: - 22.5 to 11.2) than StO₂ (mean bias: - 19.3; limits: - 36.5 to - 2.1). Most patients were classified as normal by rSO₂ but borderline by StO₂.
conclusionA transition from INVOS 5100C to tNIRS-1 is not currently feasible due to clinically significant discrepancies. Therefore, it may be appropriate to either select the device based on the specific measurement objectives or use both devices in a complementary manner.
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