Evidence map›Paper›PMID 40643554›Full record

ArticleCells2025

Dissecting the Immunological Microenvironment of Glioma Based on IDH Status: Implications for Immunotherapy.

Miyu Kikuchi, Hirokazu Takami, Yukari Kobayashi, Koji Nagaoka, Yosuke Kitagawa, Masashi Nomura, Shunsaku Takayanagi, Shota Tanaka, Nobuhito Saito, Kazuhiro Kakimi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Miyu KikuchiDepartment of Neurosurgery, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo 113-8655, Japan.
Hirokazu TakamiDepartment of Neurosurgery, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo 113-8655, Japan.ORCID 0000-0001-9742-7462
Yukari KobayashiDepartment of Immunology, Kindai University Faculty of Medicine, Osakasayama 589-8511, Osaka, Japan.
Koji NagaokaDepartment of Immunology, Kindai University Faculty of Medicine, Osakasayama 589-8511, Osaka, Japan.
Yosuke KitagawaDepartment of Neurosurgery, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo 113-8655, Japan.ORCID 0000-0002-1903-1283
Masashi NomuraDepartment of Neurosurgery, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo 113-8655, Japan.
Shunsaku TakayanagiDepartment of Neuro-Oncology, International Medical Center, Saitama Medical University, Hidaka 350-1298, Saitama, Japan.
Shota TanakaDepartment of Neurological Surgery, Okayama Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama 700-8558, Okayama, Japan.
Nobuhito SaitoDepartment of Neurosurgery, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo 113-8655, Japan.
Kazuhiro KakimiDepartment of Immunology, Kindai University Faculty of Medicine, Osakasayama 589-8511, Osaka, Japan.ORCID 0000-0003-2631-3040

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gliomas, particularly IDH-wildtype ones, are associated with poor prognosis, yet their immunological landscape remains uncertain. We analyzed RNA sequencing data from 55 glioma patients, estimating immune infiltration with CIBERSORTx and immune cell states via Ecotyper. IDH-wildtype gliomas showed significantly higher immune cell infiltration (

Indexed as

Brain NeoplasmsGliomaImmunotherapyIsocitrate DehydrogenaseTumor MicroenvironmentFemaleHumansLymphocytes, Tumor-InfiltratingMutationT-Lymphocytes, RegulatoryIsocitrate DehydrogenaseCIBERSORTxEcotypergliomaIDH statusimmune checkpoint inhibitorsimmunotherapyRNA-Seqtumor-infiltrating lymphocytestumor microenvironment

Identifiers

PMID40643554
PMCPMC12249363

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.