Hyperalgesia in the Psychological Stress-Induced Fibromyalgia Model Shows Sexual Dimorphism Mediated by LPA

Hiroshi Ueda, Hiroyuki Neyama, Naoki Dozono, Junken Aoki, Jerold Chun

Abstract read

In one paragraph

Article in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Hiroshi UedaDepartment of Pharmacology and Therapeutic Innovation, Nagasaki University Institute of Biomedical Sciences, Nagasaki 852-8521, Japan.

Hiroyuki NeyamaDepartment of Pharmacology and Therapeutic Innovation, Nagasaki University Institute of Biomedical Sciences, Nagasaki 852-8521, Japan.ORCID 0000-0003-3351-9813

Naoki DozonoDepartment of Pharmacology and Therapeutic Innovation, Nagasaki University Institute of Biomedical Sciences, Nagasaki 852-8521, Japan.

Junken AokiDepartment of Health Chemistry, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo 113-0033, Japan.

Jerold ChunCenter for Neurological Diseases, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA.ORCID 0000-0003-3964-0921

Funding

Japan Agency for Medical Research and Development 16am0101012j0005Japan Society for the Promotion of Science JP17H01586Japan Society for the Promotion of Science JP19K21592Japan Society for the Promotion of Science JP21H03024National Science and Technology Council 113-2320-B-016-004

6 · The paper itself

Abstract

Since the initial report indicating that LPA

Indexed as

FibromyalgiaHyperalgesiaReceptors, Lysophosphatidic AcidSex CharacteristicsStress, PsychologicalAnimalsDisease Models, AnimalFemaleIsoxazolesMaleMiceMice, Inbred C57BLMice, KnockoutPropionates3-(4-(4-((1-(2-chlorophenyl)ethoxy)carbonyl amino)-3-methyl-5-isoxazolyl) benzylsulfanyl) propanoic acidIsoxazolesPropionatesReceptors, Lysophosphatidic Acidclodronate liposomeempathyfibromyalgiaKi16425knock-out mouseLPA1LPA3Neurometerpsychological stresssplenocytes

Identifiers

PMID40643543

DOI10.3390/cells14131022

PMCPMC12248790

What OpenQuestion holds

Textmetadata

LicenceCC BY

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.